Neuron-specific enolase and S-100B are associated with neurologic outcome after pediatric cardiac arrest.

Objective: To characterize the pattern of serum biochemical markers of central nervous system injury (neuron-specific enolase [NSE], S-100B, plasminogen activator inhibitor-1 [PAI-1]) after pediatric cardiac arrest and determine whether there is an association between biomarker concentrations and neurologic outcome.

Design: Prospective, observational study.

Setting: Urban, tertiary care children's hospital.

Association of timing, duration, and intensity of hyperglycemia with intensive care unit mortality in critically ill children.

Objective: To study the association of timing, duration, and intensity of hyperglycemia with pediatric intensive care unit (PICU) mortality in critically ill children.

Design: Retrospective cohort study.

Setting: PICU of a university-affiliated, tertiary care, children's hospital.

S-100beta protein--serum levels in children with brain neoplasms and its potential as a tumor marker.

Objective: To determine if serum S-100beta levels are elevated in children with brain neoplasms and if it can be used as a tumor marker for children with brain neoplasms.

Design: Prospective cohort study.

Setting: Urban, tertiary care, children's teaching hospital.

Cerebrospinal fluid levels of S-100beta in children and its elevation in pediatric meningitis.

Objective: To describe normal cerebrospinal fluid (CSF) levels of S-100beta in children and determine whether CSF S-100beta levels are elevated in pediatric meningitis.

Design: Cohort study.

Setting: Children's teaching hospital.

Administration of IV medications via soluset.

Complete intravenous (IV) drug administration to a pediatric patient is an important nursing intervention. Verification of the amount of flush solution that is necessary to deliver > 95% of an IV medication to the patient was the goal of a laboratory demonstration and a clinical study. In the laboratory, it was determined that three times the volume of the dead space of the IV tubing was the required volume needed to flush dye from IV administration sets.

S-100beta protein-serum levels in healthy children and its association with outcome in pediatric traumatic brain injury.

Objective: To describe normal serum levels of S-100beta in healthy children and determine whether serum S-100beta levels after traumatic brain injury are associated with outcome.

Design: Prospective cohort study.

Setting: Urban, tertiary care, children's teaching hospital.