Development of a core outcome set for open lower limb fracture.

Open lower limb fracture is life-changing, resulting in substantial morbidity and resource demand, while inconsistent outcome-reporting hampers systematic review and meta-analysis. A core outcome set establishes consensus among key stakeholders for the recommendation of a minimum set of outcomes. This study aims to define a core outcome set for adult open lower limb fracture.

What outcomes have been reported on patients following open lower limb fracture, and how have they been measured?

Open lower limb fracture is a life-changing injury affecting 11.5 per 100,000 adults each year, and causes significant morbidity and resource demand on trauma infrastructures. This study aims to identify what, and how, outcomes have been reported for people following open lower limb fracture over ten years.

Interventions for treating fractures of the distal femur in adults.

Background: Fractures of the distal femur (the far end of the thigh bone just above the knee) are a considerable cause of morbidity. Various different surgical and non-surgical treatments have been used in the management of these injuries but the best treatment remains unknown.

Objectives: To evaluate the benefits and harms of interventions for treating fractures of the distal femur in adults.

Free functional muscle transfer for upper limb paralysis - A systematic review.

Background: Functional restoration of upper limb paralysis represents a major reconstructive challenge. Free functional muscle transfer (FFMT) enables reanimation in patients with a lack of local donor tissues or delayed presentation. This systematic review summarises the evidence for FFMT in the reconstruction of upper limb paralysis.

Research priorities for the management of complex fractures: a UK priority setting partnership with the James Lind Alliance.

Objective: To determine research priorities for the management of complex fractures, which represent the shared priorities of patients, their families, carers and healthcare professionals.

Design/setting: A national (UK) research priority setting partnership.

Participants: People who have experienced a complex fracture, their carers and relatives, and relevant healthcare professionals and clinical academics involved in treating patients with complex fractures.

Open lower limb fractures in the UK trauma system: A multicentre prospective audit of current practice.

Introduction: Open fractures represent limb-threatening and life-changing injuries. Clear standards define how patients with these injuries should be managed in the UK. The study of open fractures is, therefore, a key measurable example of major trauma management as a whole.

A Quality Improvement Initiative: Supporting the Potential of Foundation Year Doctors with a "Trauma Innovation Forum".

Junior doctors rotating through departments arrive with fresh perspectives and are particularly suited for identifying problems and providing creative solutions to improve patient care. They may, however, be unfamiliar with the process of implementing an idea into practice. We recognize the need to support foundation year doctors to develop successful quality improvement projects (QIPs).

Does This Patient Have Hip Osteoarthritis?: The Rational Clinical Examination Systematic Review.

Importance: Hip osteoarthritis (OA) is a common cause of pain and disability.

Objective: To identify the clinical findings that are most strongly associated with hip OA.

Data Sources: Systematic search of MEDLINE, PubMed, EMBASE, and CINAHL from inception until November 2019.

Multicentre collaborative cohort study of the use of Kirschner wires for the management of supracondylar fractures in children.

Purpose: Supracondylar fractures of the humerus cause significant morbidity in children. Nerve damage and loss of fracture reduction are common recognised complications in patients with this injury. Uncertainty surrounds the optimal Kirschner wire configuration and diameter for closed reduction and pinning of these fractures.

Significance of cartilage endplate within herniated disc tissue.

Purpose: Disc herniations sometimes contain hyaline cartilage fragments, but their origins and significance are uncertain.

Methods: Herniations were removed surgically from 21 patients (aged 35-74 years) whose main symptom was sciatica (10 patients) or back pain (11 patients). Frozen sections, 5 µm thick, were examined histologically, and antibodies were used to label the matrix-degrading enzyme MMP 1, pro-inflammatory mediator TNFα, and cell proliferation marker Ki-67.