Publications by authors named "Henry Asare- Anane"

Article Synopsis
  • Enteric fever (EF) and acute pancreatitis (AP) can both show elevated serum lipase and amylase, complicating diagnosis and treatment delays in patients, especially in developing countries.
  • A cross-sectional study compared biochemical markers in patients with EF, AP, and healthy controls at Korle-Bu Teaching Hospital in Ghana, using blood and stool samples for analysis.
  • Results indicated that AP patients had significantly higher levels of total amylase, lipase, and elastase-1 compared to those with EF, suggesting that elastase-1 could be a reliable biomarker to differentiate between the two conditions.
View Article and Find Full Text PDF
Article Synopsis
  • Researchers investigated how mitochondrial biomarkers (acylcarnitine, cytochrome c, and citrate synthase) are linked to type 2 diabetes (T2DM) and insulin resistance.
  • The study analyzed blood samples from 170 participants, comparing those with T2DM to those without, focusing on key metrics like blood glucose and lipid levels.
  • Results indicated that T2DM patients exhibited higher levels of cytochrome c and other risk factors, suggesting that these mitochondrial markers could serve as indicators of insulin resistance in diabetes.
View Article and Find Full Text PDF

This study evaluated the levels of anti-insulin antibodies (AIAs) and the influence of some antidiabetic medications on AIA in diabetes mellitus (DM) patients with retinopathy. An observational cross-sectional study. A lower titer of AIA IgG was observed in the diabetic retinopathy (DR) and DM-only study categories compared with the control group [DR = 86 (5-560), DM-only = 50 (5-500), versus control = 200 (7-565); p = 0.

View Article and Find Full Text PDF
Article Synopsis
  • * Researchers analyzed faecal samples from 62 dogs and found significant links between diarrhoea and factors such as age, weight, breed, and dietary history, with certain conditions like not eating for three days increasing diarrhoea risk significantly.
  • * Total faecal cholesterol emerged as the most effective indicator for diagnosing acute diarrhoea, helping veterinarians assess stool frequency and texture when detailed case histories are not available.
View Article and Find Full Text PDF

Background And Aims: Cardiovascular diseases (CVDs) are among the leading causes of disability and early death in sub-Saharan Africa. Most of the current blood tests for CVD diagnosis involve performing about three test profiles; often at additional cost to patients. C-peptide, a cleavage product of proinsulin, is a promising marker that has the potential to serve as a proxy marker for diagnosing CVDs in resource-poor settings.

View Article and Find Full Text PDF

Background: Blood protein leakage, especially albumin, into the urine is the hallmark of nephrotic syndrome (NS), which poses a serious public health problem. The absence of albumin prompts the liver to produce more proteins to make up the difference. The therapeutic significance of these additional proteins in NS is not yet fully understood.

View Article and Find Full Text PDF

Introduction: Insulin resistance (IR) is one of the common chronic metabolic disorders in Africa and elsewhere. Accumulation of lipids in the body may be due to an imbalance in the metabolism of lipids, glucose and proteins. Ceramides are a sphingolipid class of lipids that are biologically active and vital in the production of more complex lipids.

View Article and Find Full Text PDF

Background And Aim: Adipocytes secrete a peptide hormone called leptin, which plays a crucial role in controlling appetite and energy expenditure. Alterations in leptin concentrations are associated with CKD-related cardiovascular problems such as hypertensive heart disease (HHD). Despite the link, data on the precise function of leptin in people with CKD and HHD is scant.

View Article and Find Full Text PDF

Background: SLC10A1 gene codes NTCP, a receptor through which the hepatitis B virus (HBV) gets access into hepatocytes - a stage of the viral cycle necessary for replication. Polymorphism variants of SLC10A1 play roles in HBV infection, viral clearance, treatment outcome, and complications, in diverse ethnic groups and countries. However, no such study has been conducted in the Ghanaian population, a country with HBV endemicity.

View Article and Find Full Text PDF

Introduction: Kisspeptin influence on male androgens is partially understood. We aimed to evaluate serum concentrations of kisspeptin among Ghanaian men with type 2 diabetes and to identify related factors that may contribute to altering circulating kisspeptin.

Methods: A cross-sectional, observational study.

View Article and Find Full Text PDF

Objective: This study aimed to evaluate dyslipidemia in Ghanaian subjects with type 2 diabetes.

Results: Hundred individuals with type 2 diabetes and 61 apparently healthy controls participated. The prevalence of hypercholesterolemia among persons with type 2 diabetes was 53%.

View Article and Find Full Text PDF

Objective: Highly active antiretroviral therapy (HAART) has considerably reduced HIV/AIDS-related morbidity and mortality; however, the therapy has been associated with the development of cardiovascular disease (CVD), and genetic predisposition factors may aggravate disease outcome. This study was aimed at investigating the relationship between haptoglobin phenotypes and risk factors of CVD in HIV patients.

Methods: A total of 105 HIV sero-positive patients on HAART and 75 HIV-infected HAART-naïve individuals were enrolled in the study.

View Article and Find Full Text PDF

Objective: This study aimed to evaluate the effect of different levels of exercise on markers of oxidative stress and selected metabolic parameters in Ghanaian young adults.

Results: Significant increases in a marker of oxidative stress malondialdehyde and antioxidants such as superoxide dismutase and uric acid were observed in the exercisers compared with the inactive group (p < 0.05).

View Article and Find Full Text PDF

Objectives: Elevated immunoglobulin levels have been strongly linked to the development and progression of inflammatory disorders such as type 2 diabetes and obesity. This study aimed to evaluate circulating immunoglobulin levels and to identify other metabolic factors that influence humoral immune response among Ghanaian subjects with type 2 diabetes.

Methods: A comparative cross-sectional study conducted at the National Diabetes Management and Research Center, Accra.

View Article and Find Full Text PDF

Background: Oxidative stress and antioxidants have been implicated in many diseases including prostate cancer and benign prostatic hyperplasia (BPH). Lipid peroxidation contributes to oxidative stress. However, new and emerging antioxidants such as paraoxonase 1 (PON1) and arylesterase (ARE) associated with lipoprotein peroxidation have not been examined in BPH patients.

View Article and Find Full Text PDF

Objective: This study aimed to evaluate serum leptin and high sensitivity C-reactive protein (hsCRP) concentrations in obese Ghanaians with or without type 2 diabetes and to find out the extent to which their levels are influenced by underlying disorders.

Results: Obese subjects with type 2 diabetes had lower leptin but higher hsCRP levels compared with obese non-diabetic controls. There were negative correlations within the control group for glucose vs % muscle mass (r = - 0.

View Article and Find Full Text PDF

Background: Leptin levels start increasing from the early stages of pregnancy, irrespective of the maternal body mass index. Leptin levels are increased in pregnant women with preeclampsia (PE) and may precede the clinical onset of the disease, with peaks occurring around 28 weeks of gestation. This study was aimed at determining whether serum leptin concentration and body fat percentage are significantly altered during the first trimester in pregnancies that subsequently develop PE and whether such changes are useful in predicting the disease.

View Article and Find Full Text PDF
Article Synopsis
  • Impaired angiogenesis contributes to organ damage in diabetes and hypertension, prompting a study on the levels of angiogenic growth factors (Ang-1, Ang-2, VEGF) and their connection to renal function (eGFR).
  • In a case-control study of 200 participants, it was found that T2DM patients exhibited higher levels of Ang-1 and Ang-2, especially in those with both diabetes and hypertension compared to controls.
  • The data indicated a significant correlation between low eGFR and increased levels of Ang-2, highlighting the potential risk factors for kidney function in these patients.
View Article and Find Full Text PDF

Renal tubular lysosomal enzyme activities like alanine aminopeptidase (AAP) and N-acetyl-β-D-glucosaminidase (NAG) have been shown to increase in patients developing diabetic nephropathy and nephrosclerosis. This study aimed to determine the activities of N-acetyl-β-D-glucosaminidase and alanine aminopeptidase and albumin concentration in urine samples of patients with type 2 diabetes. One hundred and thirty (65 type 2 diabetic and 65 nondiabetic) subjects participated in this study.

View Article and Find Full Text PDF

Objective: Shift work has been implicated in cardiovascular disease (CVD), a major cause of death globally. The aim of this study was to evaluate the risk of developing CVD in shift work.

Design: A cross-sectional study involving secondary analysis of shift and non-shift work from an industry in Ghana.

View Article and Find Full Text PDF

Testosterone plays a vital role in obesity, glucose homeostasis, and lipid metabolism. The aim of this study was to investigate androgen levels and its association with obesity in Ghanaian men with type 2 diabetes. The study showed that serum total and free testosterone concentrations were lower in male patients with type 2 diabetes and that obesity was strongly associated with low levels of total and free testosterone in Ghanaian men with type 2 diabetes.

View Article and Find Full Text PDF

Leaves of the Gymnema sylvestre (GS) plant have been used to treat diabetes mellitus for millennia, but the previously documented insulin secretagogue effects of GS extracts in vitro may be non-physiological through damage to the beta-cells. We have now examined the effects of a novel GS extract (termed OSA) on insulin secretion from the MIN6 beta-cell line and isolated human islets of Langerhans. Insulin secretion from MIN6 cells was stimulated by OSA in a concentration-dependent manner, with low concentrations (0.

View Article and Find Full Text PDF

Defective insulin secretion in response to glucose is an important component of the beta cell dysfunction seen in type 2 diabetes. As mitochondrial oxidative phosphorylation plays a key role in glucose-stimulated insulin secretion (GSIS), oxygen-sensing pathways may modulate insulin release. The von Hippel-Lindau (VHL) protein controls the degradation of hypoxia-inducible factor (HIF) to coordinate cellular and organismal responses to altered oxygenation.

View Article and Find Full Text PDF

Croton klozchianus is a relatively uninvestigated species with no pharmacological or phytochemical reports available, although it has been used clinically by Ayurvedic physicians to treat diabetes. We have investigated this use by studying the insulin secretion and antidiabetic activity of C. klozchianus.

View Article and Find Full Text PDF

Desmodium gangeticum is widely used in the indigenous system of medicine in India and is reported to contain flavone and isoflavonoid glycosides. It forms the ingredient of many Ayurvedic formulations used for diabetes. The present study was thus aimed at evaluating the insulin secretion and antidiabetic activity of Desmodium gangeticum.

View Article and Find Full Text PDF