Insights Gained From an Ultrarare Case of Progressive Osseous Heteroplasia With Severe Complications.

Progressive osseous heteroplasia (POH) is an exceptionally rare genetic disorder characterized by progressive heterotopic ossification of cutaneous, subcutaneous, and deep connective tissues. Most cases are associated with paternally inherited inactivating mutations in the guanine nucleotide-binding protein, alpha-stimulating gene. However, the genetic basis remains undefined in a subset of patients, adding further complexity to its pathogenesis.

The effectiveness of family participation interventions for the prevention of delirium in intensive care units: A systematic review.

Aim: To review the effect of family participation interventions in preventing delirium in Intensive Care Units (ICU).

Methods: The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and the "Synthesis Without Meta-analysis" guidelines. The search was performed using the MEDLINE, CINAHL, Cochrane Database of Systematic Reviews, Web of Science, Scopus, Cochrane Central Register of Controlled Trials and ClinicalTrials.

Psychometric Analysis of the eHealth Literacy Scale in Portuguese Older Adults (eHEALS-PT24): Instrument Development and Validation.

Background: In this era of digitalization, eHealth interventions are used to engage patients in health care and help them manage their health. Previous studies showed that this can be particularly interesting for chronic disease self-management and self-care in older adults. Despite older adults becoming increasingly active on the internet, they continue to struggle in using eHealth information due to inadequate eHealth literacy.

Inhibition of pneumococcal growth and biofilm formation by human isolates of and .

Unlabelled: In a world facing the unprecedented threat of antibiotic-resistant bacteria, targeted approaches to control colonization and prevent disease caused by common pathobionts offer a promising solution. (pneumococcus) is a leading cause of infections worldwide, affecting both children and adults despite available antimicrobials and vaccines. Colonization, which occurs in the form of a biofilm in the upper respiratory tract, is frequent and a prerequisite for disease and transmission.

Fatal Bluetongue Virus Serotype 3 Infection in Female Dogs: A Case Report from Alentejo, Portugal, 2024.

The first official case of bluetongue virus serotype 3 (BTV-3) in Portugal was confirmed in sheep from the district of Évora in September 2024. Notably, mortality was observed in pregnant sheepdogs within the affected sheep flocks. This study presents four cases of pregnant dogs infected with BTV-3 in mid-September 2024, all of which aborted prior to death.

An integrated airborne transmission risk assessment model for respiratory viruses: short- and long-range contributions.

This study presents an advanced airborne transmission risk assessment model that integrates both short- and long-range routes in the spread of respiratory viruses, building upon the CERN Airborne Model for Indoor Risk Assessment (CAiMIRA) and aligned with the new World Health Organization (WHO) terminology. Thanks to a two-stage exhaled jet approach, the model accurately simulates short-range exposures, thereby improving infection risk predictions across diverse indoor settings. Key findings reveal that in patient wards, the short-range viral dose is 10-fold higher than the long-range component, highlighting the critical role of close proximity interactions.

Hip fractures in older patients: analysing the activity of an orthopaedic department to design an optimized pathway of fracture care.

Unlabelled: Substandard management of hip fractures in older patients has serious consequences in outcomes. Assessing care provided and institutional characteristics is essential to identify aspects to improve for better results. Delay to surgery, inadequate pain management, and delay in urinary catheter removal were especially inadequate and needed correction to better patient recovery.

Cannabinoid spoilage, metabolism and cannabidiol(CBD) conversion to Tetrahydrocannabinol(THC) mechanisms with energetic parameters.

Chemical redox mechanisms and thermodynamic parameters of the Cannabinoids Δ-Tetrahydrocannabinol (THC) and cannabidiol (CBD) were determined theoretically and using activated complex theory then compared to physical experimentations of chemical spoilage by Pholsiri T et al. and intramolecular conversion of CBD to thc by Daniels. R.

Use of amantadine in traumatic brain injury: an updated meta-analysis of randomized controlled trials.

Introduction: Amantadine has been shown to accelerate cognitive and functional brain recovery after cerebrovascular accidents. However, the efficacy of this drug in TBI patients remains poorly defined.

Methods: We performed a systematic review and meta-analysis of randomized trials (RCTs) evaluating the effects of amantadine in TBI patients.

Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome Associated With Celecoxib: A Case Report of a Rare Entity.

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe, drug-induced hypersensitivity reaction characterized by widespread skin rash, multi-system involvement, and often eosinophilia. While anticonvulsants, allopurinol, and antibiotics are the most implicated agents, non-steroidal anti-inflammatory drugs (NSAIDs) such as celecoxib can be triggers in rare cases. We report the case of a 63-year-old female presenting with a 10-day history of jaundice, nausea, and right upper quadrant pain following repeated use of celecoxib.

Evidence from a mouse model supports repurposing an anti-asthmatic drug, bambuterol, against Alzheimer's disease by administration through an intranasal route.

Bambuterol is a long-acting anti-asthmatic prodrug which releases terbutaline. Terbutaline is an agonist of the β-adrenergic receptors which is formed by decarbamoylation of bambuterol by butyrylcholinesterase. Inhibition of the latter, as well as activation of β-AR, are of interest for the treatment of Alzheimer's disease (AD).

Fourier Transform Infrared Spectroscopy Analysis as a Tool to Address Aβ Impact on Extracellular Vesicles.

Alzheimer's disease is a challenge in modern healthcare due to its complex etiology and increasing prevalence. Despite advances, further understanding of Alzheimer's disease pathophysiology is needed, particularly the role of Aβ neurotoxic peptide. Fourier transform infrared spectroscopy (FTIR) has shown potential as a screening tool for several pathologies, including Alzheimer's disease.

Embedding a ribonuclease in the spore crust couples gene expression to spore development in Bacillus subtilis.

Faced with nutritional stress, some bacteria form endospores capable of enduring extreme conditions for long periods of time; yet the function of many proteins expressed during sporulation remains a mystery. We identify one such protein, KapD, as a 3'-exoribonuclease expressed under control of the mother cell-specific transcription factors SigE and SigK in Bacillus subtilis. KapD dynamically assembles over the spore surface through a direct interaction with the major crust protein CotY.

New Potent Inhibitor of Transforming Growth Factor-Beta (TGFβ) Signaling that is Efficacious against Microsatellite Stable Colorectal Cancer Metastasis in Combination with Immune Checkpoint Therapy in Mice.

Blockade of the TGFβ signaling pathway has emerged from preclinical studies as a potential treatment to enhance the efficacy of immune checkpoint inhibition in advanced colorectal cancer (CRC) and several other types of cancer. However, clinical translation of first-generation inhibitors has shown little success. Here, we report the synthesis and characterization of HYL001, a potent inhibitor of TGFβ receptor 1 (ALK5), that is approximately 9 times more efficacious than the structurally related compound galunisertib, while maintaining a favorable safety profile.

Peripheral Axonal Neuropathy in Hemophagocytic Lymphohistiocytosis Secondary to Rickettsia conorii Infection.

Hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially fatal hyperinflammatory syndrome characterized by dysregulated immune activation and systemic inflammation. Secondary HLH is often triggered by infections, with being an infrequently reported cause. Peripheral axonal neuropathy is a rare and poorly understood complication of HLH.

CheckAP: Prevalence of psoriatic arthritis (PsA) and performance evaluation of the EARP questionnaire in the population of Portuguese patients with psoriasis followed in a dermatology setting.

Background: The percentage of Portuguese psoriasis patients with psoriatic arthritis is unknown but musculoskeletal complaints related to PsA affect up to a third of patients. Dermatologists can identify early PsA as skin symptoms often precede joint symptoms in 80% of patients. Efficient and easy to perform screening tools are needed to help dermatologists effectively discriminate between Pso and PsA patients.

Preparation of a As source sample for application in an offline ion source.

For the generation of beams with the offline ion source at the Facility for Rare Isotope Beams (FRIB), suitable source samples are required. Arsenic-73 is a frequently requested user beam due to its significance in nuclear structure studies and astrophysics. In this work, we outline the process of preparing a As source sample, containing (5.

The Effectiveness of eHealth Interventions in Promoting the Health Literacy of Informal Caregivers: A Systematic Literature Review Protocol.

Background: Digital Information and Communication Technologies (ICTs) offer significant opportunities to enhance public health, particularly through their strategic use in promoting health literacy.

Objectives: This systematic review protocol aims to outline the methodological steps necessary to conduct a systematic review of the effectiveness of digital interventions in improving health literacy among informal caregivers.

Methods: This review will include studies involving adult informal caregivers (≥18 years) undergoing a digital health intervention promoting health literacy.

Treatment of a Gingival Recession With In-Office Orthodontic Aligners and Gingival Graft.

Objective: Gingival recession is a complication that can occur after orthodontic treatment, and its cause is still very controversial in the literature. The objective of this study was to report a clinical case of orthodontic retreatment conducted with in-office aligners and root coverage using free gingival graft, connective tissue graft, and Emdogaim for a patient with severe gingival recession.

Clinical Considerations: This report presents a potential solution to correct a gingival recession with in-office clear aligner.

Catalytic peptide-based coacervates for enhanced function through structural organization and substrate specificity.

Liquid-liquid phase separation (LLPS) in living cells provides innovative pathways for synthetic compartmentalized catalytic systems. While LLPS has been explored for enhancing enzyme catalysis, its potential application to catalytic peptides remains unexplored. Here, we demonstrate the use of coacervation, a key LLPS feature, to constrain the conformational flexibility of catalytic peptides, resulting in structured domains that enhance peptide catalysis.