Calyptranthes grandifolia O.Berg (Myrtaceae) ethanolic extract inhibits TNF-α gene expression and cytokine release in vitro.

Anti-tumor therapies based on anti-inflammatory effects have been considered in cancer treatment. Survival, proliferation and, resultantly, invasion and metastasis of tumor cells are regulated by local inflammatory mediators. Primary inflammatory cytokines, such as tumor necrosis factor (TNF), are targets for anticancer therapy.

Effect of on , and mRNA expression levels in human gastric mucosa.

infects ~50% of the world population, causing chronic gastritis and other forms of cellular damage. The present study assessed the influence of on the mRNA expression levels of nuclear factor-κB1 (), and tumor necrosis factor-α () in human gastric mucosa in a southern Brazilian population. Human gastric tissue was collected by upper endoscopy and diagnosis was performed using a rapid urease test and histological analysis.