Publications by authors named "Henrique Jefferson de Arruda"
Article Synopsis
- - The study focused on creating and analyzing new coumarin-imidazopyridine hybrid ligands and their zinc(II) complexes, achieving a successful synthesis with yields between 56-90%.
- - The synthesized complexes showed significant antiviral effects against the Zika virus, with some demonstrating better activity than the standard antiviral ribavirin.
- - Investigations into how these compounds work revealed they can disrupt both viral entry and replication, providing insights into their mechanisms and potential for further development.
Although there are various treatment options for cancer, this disease still has caused an increasing number of deaths, demanding more efficient, selective and less harmful drugs. Several classes of ruthenium compounds have been investigated as metallodrugs for cancer, mainly after the entry of imidazolH [-RuCl-(DMSO-S)(imidazole)] (NAMI-A) and indazolH [-RuCl-(Indazol)] (KP1019) in clinical trials. In this sense, Ru complexes with general formula [Ru(L1-3)(bipy)]PF (1-3) (L1 = ethyl 3-(6-methyl-2-oxo-2-chromen-3-yl)-3-oxopropanoate, L2 = ethyl 3-(7-(diethylamino)-2-oxo-2-chromen-3-yl)-3-oxopropanoate, L3 = ethyl 3-(8-methoxy-2-oxo-2-chromen-3-yl)-3-oxopropanoate and bipy = bipyridine) have been synthesized.
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