Publications by authors named "Henrique Atalaia-Barbacena"
Unlabelled: Cytomegalovirus (CMV) is a human herpes virus with a worldwide seroprevalence of 60-100%, mainly known to cause severe life-threatening disease in immunocompromised patients. In immunocompetent hosts (IMCh), CMV causes a self-limiting mononucleosis-like infection, and severe pictures are less recognized. We report a case of a previously healthy 62-year-old woman evaluated in the Internal Medicine outpatient clinic for 3 weeks of progressive fatigue, generalised inflammatory arthralgias, hypogastric discomfort and daily persistent fever.
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- In Alzheimer's disease, amyloid beta (Aβ) triggers the cleavage of the TrkB-FL receptor, disrupting essential BDNF signaling that is crucial for neuron health and function.
- Researchers found that TrkB-FL cleavage occurs early in the disease and worsens with increased pathology, using human samples and cerebrospinal fluid for their studies.
- They developed a TAT-TrkB peptide that successfully prevents TrkB-FL cleavage, showing potential in improving cognitive function and synaptic issues in a mouse model of Alzheimer's, indicating it could be a safe and effective treatment option.
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- Tuberculosis (TB) is a major global health concern, causing significant illness and death, and can manifest in various forms, including pulmonary (PTB) and extrapulmonary (EPTB) diseases.
- One rare hematological complication associated with TB is immune thrombocytopenic purpura (ITP), which was observed in a case involving a 22-year-old woman with ganglionic tuberculosis.
- Treatment of this case involved a combination of intravenous immunoglobulin, high-dose corticosteroids, and anti-tubercular therapy, leading to positive results.
Unlabelled: Syphilis, a disease caused by the bacteria , has a multitude of clinical manifestations and is classified into primary syphilis, secondary syphilis and tertiary syphilis, based on clinical presentations and the time elapsed since the primary infection. The secondary stage of the disease can affect multiple organs and systems, and some of these involvements may be general and non-specific, justifying its name as 'the great imitator'. We present a case of a 30-year-old woman with a history of painful neck lymph nodes with progressive enlargement, persistent headache, weight loss, myalgia and alopecia.
View Article and Find Full Text PDFIntroduction: Long-COVID-19 impacts health-related quality of life (HR-QoL) but data is scarce. The aim of this study was to describe and prospectively assess the prevalence and risk factors for long-COVID-19 after hospital discharge, and to evaluate its impact on patient HR-QoL.
Material And Methods: Single-centre longitudinal study including all COVID-19 patients discharged between December 2020 and February 2021.
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients with cancer show worse outcomes compared with patients without cancer. The humoral immune response (HIR) of patients with cancer against SARS-CoV-2 is not well characterized. To better understand it, we conducted a serological study of hospitalized patients with cancer infected with SARS-CoV-2.
View Article and Find Full Text PDFSeveral observational studies suggest that greasy fish may reduce cardiovascular risk, whose benefits have been attributed to the presence Omega-3 polyunsaturated fatty acids (OM3FA). However, there are some randomized controlled trials (RCTs) that have shown contradictory results concerning the cardiovascular benefits of OM3FA. Analyzing these RCTs we found that the use of olive oil in some RCTs could be responsible for contradictory results, since both.
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