Publications by authors named "Henrike Wilms"
Front Cell Neurosci
March 2023
Article Synopsis
- Selective loss of inhibitory interneurons (INs) in the subiculum may lead to increased excitatory activity, potentially triggering epileptic seizures, particularly in mesial temporal lobe epilepsy (MTLE).
- Research using a kainate mouse model revealed significant cell loss in the subiculum along with changes in IN subpopulations, particularly a 50% reduction in parvalbumin (PV) and calretinin (CR) expressing INs.
- Although there was an increase in neuropeptide Y (NPY) positive neurons, the increase was attributed to non-GABAergic neurons rather than a rise in NPY-expressing INs, indicating a unique vulnerability among these cells in MTLE.
