Heart immunoengineering by lentiviral vector-mediated genetic modification during normothermic perfusion.

Heart transplantation is associated with major hurdles, including the limited number of available organs for transplantation, the risk of rejection due to genetic discrepancies, and the burden of immunosuppression. In this study, we demonstrated the feasibility of permanent genetic engineering of the heart during perfusion. Lentiviral vectors encoding for short hairpin RNAs targeting beta2-microglobulin (shβ2m) and class II transactivator (shCIITA) were delivered to the graft during two hours of normothermic EVHP.

[Care for family carers of people with dementia in municipal communities during the pandemic: A Qualitative Study].

Care for family carers of people with dementia in municipal communities during the pandemic: A Qualitative Study The availability of support services for family carers of persons with dementia in the municipal community shows deficits due to the Corona pandemic and thus entails a change in the support of carers. The questions arise, what changes in the care of family carers of people with dementia do those affected perceive, how do actors from the municipal community experience the care situation during the pandemic and to what extent do the perceptions of the groups coincide or differ. The database consists of town hall talks and focus groups from 13 municipal communities in Germany.

Community support for caring relatives of people with dementia: qualitative analysis using the Theoretical Domains Framework.

Aim: Although caring relatives of people with dementia are a mainstay of many care systems, the availability of support services for them within the municipal community shows deficiencies. Adopting the Theoretical Domains Framework (TDF) this study aims to investigate 1) which of the TDF domains adapted to gerontology show up in public dialogue, and 2) the results that public dialogues produce in terms of support services for caring relatives.

Subject And Methods: The data consists of town hall meetings and focus groups from 14 municipal communities in Germany.

[Advance care planning (ACP) in the context of dementia : Development of an instrument for exploration of perspectives of affected persons].

Background: Since 2015, the Hospice and Palliative Care Act has defined the entitlement of nursing home residents to preventive planning in the final phase of their lives. Nevertheless, the advance care planning (ACP) concept has not yet been sufficiently researched in Germany. The deficient evidence on this topic appears to be even more considerable in connection with dementia.