Online adaptive radiotherapy potentially reduces toxicity for high-risk prostate cancer treatment.

Background And Purpose: With daily, MR-guided online adapted radiotherapy (MRgART) it may be possible to reduce the PTV in pelvic RT. This study investigated the potential reduction in normal tissue complication probability (NTCP) of MRgART compared to standard radiotherapy for high-risk prostate cancer.

Materials And Methods: Twenty patients treated with 78 Gy to the prostate and 56 Gy to elective pelvic lymph nodes were included.

End-to-end validation of the geometric dose delivery performance of MR linac adaptive radiotherapy.

The clinical introduction of hybrid magnetic resonance (MR) guided radiotherapy (RT) delivery systems has led to the need to validate the end-to-end dose delivery performance on such machines. In the current study, an MR visible phantom was developed and used to test the spatial deviation between planned and delivered dose at two 1.5 T MR linear accelerator (MR linac) systems, including pre-treatment imaging, dose planning, online imaging, image registration, plan adaptation, and dose delivery.

First clinical experiences with a high field 1.5 T MR linac.

A 1.5 T MR Linac (MRL) has recently become available. MRL treatment workflows (WF) include online plan adaptation based on daily MR images (MRI).

Adapting automated treatment planning configurations across international centres for prostate radiotherapy.

Background And Purpose: Automated configurations are increasingly utilised for radiotherapy treatment planning. This study investigates whether automated treatment planning configurations are adaptable across clinics with different treatment planning protocols for prostate radiotherapy.

Material And Methods: The study comprised three participating centres, each with pre-existing locally developed prostate AutoPlanning configurations using the Pinnacle® treatment planning system.

Magnetic resonance only workflow and validation of dose calculations for radiotherapy of prostate cancer.

Background: Current state of the art radiotherapy planning of prostate cancer utilises magnetic resonance (MR) for soft tissue delineation and computed tomography (CT) to provide an electron density map for dose calculation. This dual scan workflow is prone to setup and registration error. This study evaluates the feasibility of an MR-only workflow and the validity of dose calculation from an MR derived pseudo CT.

Stereotactic body radiation therapy versus conventional radiation therapy in patients with early stage non-small cell lung cancer: an updated retrospective study on local failure and survival rates.

Introduction: Stereotactic body radiation therapy (SBRT) for early stage non-small cell lung cancer (NSCLC) is now an accepted and patient friendly treatment, but still controversy exists about its comparability to conventional radiation therapy (RT). The purpose of this single-institutional report is to describe survival outcome for medically inoperable patients with early stage NSCLC treated with SBRT compared with high dose conventional RT.

Material And Methods: From August 2005 to June 2012, 100 medically inoperable patients were treated with SBRT at Odense University Hospital.

Effect of the vitamin B12-binding protein haptocorrin present in human milk on a panel of commensal and pathogenic bacteria.

Background: Haptocorrin is a vitamin B12-binding protein present in high amounts in different body fluids including human milk. Haptocorrin has previously been shown to inhibit the growth of specific E. coli strains, and the aim of the present study was to elucidate whether the antibacterial properties of this protein may exert a general defense against pathogens and/or affect the composition of the developing microbiota in the gastrointestinal tracts of breastfed infants.

Reduction of Cone-Beam CT scan time without compromising the accuracy of the image registration in IGRT.

Background: In modern radiotherapy accelerators are equipped with 3D cone-beam CT (CBCT) which is used to verify patient position before treatment. The verification is based on an image registration between the CBCT acquired just before treatment and the CT scan made for the treatment planning. The purpose of this study is to minimise the scan time of the CBCT without compromising the accuracy of the image registration in IGRT.

The representitativeness of patient position during the first treatment fractions.

Background: During external radiotherapy daily or even weekly image verification of the patient position might be problematic due to the resulting workload. Therefore it has been customary to perform image verification only at the first treatment fraction. In this study it is investigated whether the patient position uncertainty at the initial three treatment fractions is representative for the uncertainty throughout the treatment course.

Cone beam CT evaluation of patient set-up accuracy as a QA tool.

Purpose: To quantify by means of cone beam CT the random and systematic uncertainty involved in radiotherapy, and to determine if this information can be used for e.g. technical quality assurance, evaluation of patient immobilization and determination of margins for the treatment planning.

Inter- and intrafractional movement of the tumour in extracranial stereotactic radiotherapy of NSCLC.

Purpose: The purpose of this study is to determine the inter- and intra-fractional respiration induced tumour movements as well as setup accuracy in a stereotactic body frame for stereotactic treatments of NSCLC patients.

Patients And Methods: From August 2005 to March 2008, 26 patients with NSCLC where given a stereotactic treatment. The patients were scanned with normal and uncoached respiration without use of abdominal compression.