Synthesis and Antifungal Activity of Fmoc-Protected 1,2,4-Triazolyl-α-Amino Acids and Their Dipeptides Against Species.

In recent years, fungal infections have emerged as a significant health concern across veterinary species, especially in livestock such as cattle, where fungal diseases can result in considerable economic losses, as well as in humans. In particular, species, notably and , are opportunistic pathogens that pose a threat to both animals and humans. This study focuses on the synthesis and antifungal evaluation of novel 9-fluorenylmethoxycarbonyl (Fmoc)-protected 1,2,4-triazolyl-α-amino acids and their dipeptides, designed to combat fungal pathogens.

A Simple and Easily Implemented Method for the Regioselective Introduction of Deuterium into Azolo[1,5-]pyrimidines Molecules.

A method for the technically easy-to-implement synthesis of deuterium-labeled pyrazolo[1,5-]pyrimidines and 1,2,4-triazolo[1,5-]pyrimidines have been developed. The regioselectivity of such transformations has been shown. H NMR and mass spectrometric methods have proved the quantitative nature of such transformations and the kinetics of deuterium exchange has been studied.