Publications by authors named "Henrik K Jensen"
Article Synopsis
- - The study investigated the higher risk of sinus node dysfunction (SND) that leads to pacemaker implantation and mortality among first-degree relatives of patients with pacemakers due to SND.
- - Data was collected from various Danish health registries, tracking over 6 million individuals from 1982 to 2022, and findings indicated that those with a family history of SND had a significantly higher risk (RR = 2.9) of requiring a pacemaker compared to the general population.
- - While overall mortality rates among these relatives were similar to the general population, there was a notable increase in mortality for those related to patients with early-onset SND (RR = 1.22), indicating a possible genetic
Up to 70% of all sudden cardiac deaths (SCD) in persons under 50 years are due to inherited cardiovascular diseases. First-degree relatives to younger SCD patients should be evaluated for inherited cardiovascular disease, as argued in this review. An improved understanding of SCD subtypes and genetics is expected to improve risk stratification and SCD prevention.
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- Genetic findings play a crucial role in treating patients with hereditary cardiac diseases, but the classification of genetic variants can change over time, leading to significant manual reevaluation costs.
- The study involved analyzing genetic variants from nearly 3,000 patients suspected of specific cardiac conditions, comparing old classifications with results from an automated variant classifier to identify those needing manual reevaluation.
- Results showed that the autoclassifier effectively pinpointed variants with potential clinical impact, suggesting its use could streamline the reevaluation process and enhance patient care.
Background: Electrogram dispersion identifies putative atrial fibrillation (AF) drivers in first time ablation procedures, with high acute termination rates and long-term outcomes akin to extensive ablation approaches. Its use in a population that had undergone repeat ablation is unknown, particularly where the pulmonary veins are already isolated.
Objective: This purpose of this study was to assess electrogram dispersion mapping during repeat ablation procedures for persistent AF.
Article Synopsis
- Electrocardiographic abnormalities are common in patients with arrhythmogenic right ventricular cardiomyopathy and were analyzed over the long term in a study involving 353 patients and almost 7,000 ECGs.
- The study found that over time, there were notable changes in QRS voltage, R- and T-wave amplitudes, as well as increases in QRS duration, terminal activation duration, and QTc interval, indicating a progressive worsening of the condition.
- T-wave inversions observed before diagnosis were linked to a higher risk of future ventricular arrhythmias, suggesting these ECG abnormalities could serve as early indicators of the disease even if they don't meet the full diagnostic criteria.
encodes for the Popeye domain-containing protein 2 which has an important role in cardiac pacemaking and conduction, due in part to its cAMP-dependent binding and regulation of TREK-1 potassium channels. Loss of in mice results in sinus pauses and bradycardia and morpholino knockdown of zebrafish results in atrioventricular (AV) block. We identified bi-allelic variants in in 4 families that presented with a phenotypic spectrum consisting of sinus node dysfunction, AV conduction defects and hypertrophic cardiomyopathy.
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- - The text discusses Calcium Release Deficiency Syndrome (CRDS), a serious genetic heart condition that can cause sudden cardiac arrest without clear reasons and is not detectable through standard tests.
- - The study aimed to analyze electrocardiogram (ECG) responses after brief periods of fast heart rates followed by pauses in order to develop a diagnostic test for CRDS.
- - Findings showed that patients with CRDS had a significantly greater change in T-wave amplitude on their ECG after a pause compared to control groups, indicating a potential diagnostic marker for this syndrome.
Article Synopsis
- Individuals with both atrial fibrillation (AF) and myocardial infarction (MI) experience higher mortality rates compared to those with only one of the conditions, and the study explores how the order in which these conditions occur may affect mortality.
- The Framingham Heart Study data, spanning from 1960 onward, was analyzed with over 10,000 participants to determine the hazard ratios of developing AF and MI, revealing that having interim MI significantly increases the risk of new-onset AF, and vice versa.
- The findings indicate a strong bidirectional relationship between AF and MI, with those suffering from both conditions facing substantially greater mortality risks, irrespective of which condition appeared first.
Background And Aims: Implantable cardioverter-defibrillators (ICDs) are critical for preventing sudden cardiac death (SCD) in arrhythmogenic right ventricular cardiomyopathy (ARVC). This study aims to identify cross-continental differences in utilization of primary prevention ICDs and survival free from sustained ventricular arrhythmia (VA) in ARVC.
Methods: This was a retrospective analysis of ARVC patients without prior VA enrolled in clinical registries from 11 countries throughout Europe and North America.
Article Synopsis
- - The study investigated how lifestyle factors interact with genetic predisposition to affect the risk of developing atrial fibrillation (AF) in a cohort of Danish participants, finding that both play crucial roles in AF incidence.
- - Researchers categorized participants based on their lifestyle choices (poor, intermediate, ideal) and genetic risk scores, discovering that incidence rates of AF were higher among those with worse lifestyles, regardless of genetic risk.
- - The results indicated a significant interaction between lifestyle and genetic risk, highlighting that improving lifestyle factors is especially important for individuals with a high genetic predisposition to AF.
Article Synopsis
- Obesity is linked to a higher risk of atrial fibrillation (AF), and this study examines how weight changes over five years affect that risk.
- The research analyzed data from over 43,000 participants in Denmark, finding that weight gain significantly increased the risk of developing AF, while weight loss did not show a notable effect.
- Specifically, gaining between 2.5 and 5 BMI units raised the risk by 24%, and gains of 5 or more BMI units nearly doubled the risk of incident AF compared to stable weight.
Article Synopsis
- Genetic variants in the cardiac sodium channel Na1.5 are linked to various inherited arrhythmias, including sick sinus syndrome, atrial fibrillation, and sudden cardiac death, with both loss-of-function and gain-of-function variants playing significant roles.
- The rare Multifocal Ectopic Purkinje-related Premature Contractions (MEPPC) syndrome, characterized by frequent premature contractions and often accompanied by dilated cardiomyopathy (DCM), is inherited in an autosomal dominant manner.
- Treatment for MEPPC-related DCM is challenging, but class 1c sodium channel inhibitors like flecainide have shown positive effects, emphasizing the need for genetic screening in affected patients.
Article Synopsis
- Calmodulinopathy is caused by mutations in CALM genes and leads to serious arrhythmias, particularly in young people; the ICalmR aims to connect clinical symptoms with molecular causes.
- The ICalmR has gathered data from 140 patients, showing a notable presence of CALM-LQTS and CALM-CPVT, and has observed a decrease in the frequency of serious cardiac events compared to past data.
- The condition presents a wide range of symptoms, from severe arrhythmias to no symptoms at all; while therapy options are limited and based on current practices, management often involves medication and devices like defibrillators.
Article Synopsis
- A new variant in the SLC4A3 gene has been linked to short QT syndrome (SQTS), but its significance in sudden cardiac death is still unclear.
- This study examined genetic variants in SQTS patients, finding disease-causing variants in 26% of those tested, primarily in the SLC4A3 gene.
- Results indicate that SLC4A3 variants lead to changes in heart activity, confirming the need to screen for these variants in SQTS and sudden cardiac death cases.
Article Synopsis
- Recent advances in genetics allow for the calculation of polygenic risk scores (PRSs) for coronary artery disease (CAD) based on common genetic variants.
- PRSs are highly correlated with atherosclerosis levels and outperform traditional risk factors in assessing CAD risk throughout a person's life.
- Implementing PRSs in clinical settings enhances risk stratification for cardiovascular disease and offers potential benefits for diagnostics and treatment strategies in CAD and other health conditions.
Aims: Alcohol intake is a well-established risk factor for atrial fibrillation (AF). However, evidence on the effects of changes in alcohol intake to primary AF prevention is sparse. The aim of this study was to examine the association between 5-year changes in alcohol intake and the risk of incident AF.
View Article and Find Full Text PDFBackground: Population-based epidemiologic studies of aortic dissections (ADs) are needed. This study aimed to report clinical characteristics, incidences, and mortality rates for adult patients admitted to Danish hospitals with type A AD (TAAD) or type B AD (TBAD) from 1996 through 2016.
Methods: We conducted a nationwide, population-based register study.
Article Synopsis
- The study investigates workforce attachment of patients with congenital long QT syndrome (cLQTS) in Denmark from 1996 to 2016, focusing on their employment status post-diagnosis.
- It finds that over 90% of cLQTS patients remained employed one year after their diagnosis, similar to a matched control group, but with a slight drop in attachment compared to the general population.
- Severe manifestations of the condition, such as aborted cardiac arrests, significantly increase the likelihood of workforce detachment within that year.
Article Synopsis
- Heterozygous familial hypercholesterolemia (HeFH) involves LDLR mutations that lead to high cholesterol levels and increased cardiovascular risks, and the link between these mutations and cancer risk was unclear.
- A study followed 221 HeFH relatives to assess long-term cancer incidence compared to a matched general population cohort; results showed no significant difference in cancer risk for mutation carriers but a lower risk for non-mutation carriers.
- Overall, mutation-carrying HeFH relatives in Denmark had a similar cancer risk to the general population, while non-mutation carriers demonstrated reduced cancer incidence.
Arrhythmic risk prediction in arrhythmogenic right ventricular cardiomyopathy: external validation of the arrhythmogenic right ventricular cardiomyopathy risk calculator.
Eur Heart J
August 2022
Aims: Arrhythmogenic right ventricular cardiomyopathy (ARVC) causes ventricular arrhythmias (VAs) and sudden cardiac death (SCD). In 2019, a risk prediction model that estimates the 5-year risk of incident VAs in ARVC was developed (ARVCrisk.com).
View Article and Find Full Text PDFAims: Variants in SCN5A encoding Nav1.5 are associated with cardiac arrhythmias. We aimed to determine the mechanism by which c.
View Article and Find Full Text PDFOutcome after out-of-hospital cardiac arrest in patients with ischaemic and non-ischaemic heart disease: A Danish tertiary-center cohort study.
Int J Cardiol Heart Vasc
August 2022
Background: Mortality following out-of-hospital cardiac arrest (OHCA) is high, and studies on return to work show varying results. It remains uncertain whether mortality and return to work differs between patients with ischaemic heart disease (IHD) and non-ischaemic heart disease (non-IHD).
Aim: To investigate all-cause mortality, cardiac death, and return to work among patients admitted after OHCA with IHD and non-IHD.
Aims: Persistent cardiac symptoms are an increasingly reported phenomenon following COVID-19. However, the underlying cause of cardiac symptoms is unknown. This study aimed to identify the underlying causes, if any, of these symptoms 1 year following acute COVID-19 infection.
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