Transport signatures of symmetry protection in 1D Floquet topological insulators.

Time-periodic external drives have emerged as a powerful tool to artificially create topological phases of matter. Prime examples are Floquet topological insulators (FTIs), where a gapped bulk supports in-gap edge states, protected against symmetry-preserving local perturbations. Similar to an ordinary static topological insulator, the robustness of an edge state in a one-dimensional (1D) FTI shows up as a pinning of its quasienergy level, but now inside one of two distinct bulk gaps.

Measurement Quench in Many-Body Systems.

Measurement is one of the key concepts which discriminates classical and quantum physics. Unlike classical systems, a measurement on a quantum system typically alters it drastically as a result of wave function collapse. Here we suggest that this feature can be exploited for inducing quench dynamics in a many-body system while leaving its Hamiltonian unchanged.

Loschmidt Echo Revivals: Critical and Noncritical.

A quantum phase transition is generally thought to imprint distinctive characteristics on the nonequilibrium dynamics of a closed quantum system. Specifically, the Loschmidt echo after a sudden quench to a quantum critical point-measuring the time dependence of the overlap between initial and time-evolved states-is expected to exhibit an accelerated relaxation followed by periodic revivals. We here introduce a new exactly solvable model, the extended Su-Schrieffer-Heeger model, the Loschmidt echo of which provides a counterexample.

A systematic search strategy identifies cubilin as independent prognostic marker for renal cell carcinoma.

Background: There is an unmet clinical need for better prognostic and diagnostic tools for renal cell carcinoma (RCC).

Methods: Human Protein Atlas data resources, including the transcriptomes and proteomes of normal and malignant human tissues, were searched for RCC-specific proteins and cubilin (CUBN) identified as a candidate. Patient tissue representing various cancer types was constructed into a tissue microarray (n = 940) and immunohistochemistry used to investigate the specificity of CUBN expression in RCC as compared to other cancers.

Loss of ASRGL1 expression is an independent biomarker for disease-specific survival in endometrioid endometrial carcinoma.

Objective: For endometrial carcinoma, prognostic stratification methods do not satisfactorily identify patients with adverse outcome. Currently, histology, tumor grade and stage are used to tailoring surgical treatment and to determine the need for adjuvant treatment. Low-risk patients are not considered to require adjuvant therapy or staging lymphadenectomy.

SATB1 is an independent prognostic factor in radically resected upper gastrointestinal tract adenocarcinoma.

Gastric cancer is the second most common cause of cancer-related death worldwide, and the incidence of esophageal adenocarcinoma is rising. While some progress has been made in treatment strategies, overall survival remains very poor for patients with adenocarcinoma in the upper gastrointestinal tract. Special AT-rich sequence binding protein 1 (SATB1) is a global genome organizer that has been demonstrated to promote aggressive tumor behavior in several different types of cancer, including gastric cancer.

An order parameter for impurity systems at quantum criticality.

A quantum phase transition may occur in the ground state of a system at zero temperature when a controlling field or interaction is varied. The resulting quantum fluctuations which trigger the transition produce scaling behaviour of various observables, governed by universal critical exponents. A particularly interesting class of such transitions appear in systems with quantum impurities where a non-extensive term in the free energy becomes singular at the critical point.

Assessment of SOX11 expression in routine lymphoma tissue sections: characterization of new monoclonal antibodies for diagnosis of mantle cell lymphoma.

The diagnosis of mantle cell lymphoma (MCL) can be difficult, especially when no t(11;14) translocation and cyclin D1 overexpression can be detected. In such cases, the transcription factor SOX11 represents an important diagnostic marker, as it is expressed in most MCLs and, in particular, in all cyclin D1-negative MCLs reported so far. A reliable anti-SOX11 antibody is therefore a very useful tool for routine diagnosis.

Targeting HMG-CoA reductase with statins in a window-of-opportunity breast cancer trial.

Lipophilic statins purportedly exert anti-tumoral effects on breast cancer by decreasing proliferation and increasing apoptosis. HMG-CoA reductase (HMGCR), the rate-limiting enzyme of the mevalonate pathway, is the target of statins. However, data on statin-induced effects on HMGCR activity in cancer are limited.

Entanglement probe of two-impurity Kondo physics in a spin chain.

We propose that real-space properties of the two-impurity Kondo model can be obtained from an effective spin model where two single-impurity Kondo spin chains are joined via an Ruderman-Kittel-Kasuya-Yosida (RKKY) interaction between the two impurity spins. We then use a density matrix renormalization group approach, valid in all ranges of parameters, to study its features using two complementary quantum-entanglement measures, the negativity and the von Neumann entropy. This nonperturbative approach enables us to uncover the precise dependence of the spatial extent ξ(K) of the Kondo screening cloud with the Kondo and RKKY couplings.

Molecular correlates and prognostic significance of SATB1 expression in colorectal cancer.

Background: Special AT-rich sequence-binding protein 1 (SATB1) is a global gene regulator that has been reported to confer malignant behavior and associate with poor prognosis in several cancer forms. SATB1 expression has been demonstrated to correlate with unfavourable tumour characteristics in rectal cancer, but its association with clinical outcome in colorectal cancer (CRC) remains unclear. In this study, we examined the prognostic impact of SATB1 expression in CRC, and its association with important molecular characteristics; i.

Arabidopsis thaliana TERMINAL FLOWER2 is involved in light-controlled signalling during seedling photomorphogenesis.

Plants respond to changes in the environment by altering their growth pattern. Light is one of the most important environmental cues and affects plants throughout the life cycle. It is perceived by photoreceptors such as phytochromes that absorb light of red and far-red wavelengths and control, for example, seedling de-etiolation, chlorophyll biosynthesis and shade avoidance response.

High nuclear RBM3 expression is associated with an improved prognosis in colorectal cancer.

Purpose: In this study, we investigated the prognostic impact of human RBM3 expression in colorectal cancer using tissue microarray-based immunohistochemical analysis.

Experimental Design: One polyclonal antibody and four monoclonal anti-RBM3 antibodies were generated and epitope mapped using two different methods. Bacterial display revealed five distinct epitopes for the polyclonal antibody, while the four mouse monoclonal antibodies were found to bind to three of the five epitopes.

Generation of monospecific antibodies based on affinity capture of polyclonal antibodies.

A method is described to generate and validate antibodies based on mapping the linear epitopes of a polyclonal antibody followed by sequential epitope-specific capture using synthetic peptides. Polyclonal antibodies directed towards four proteins RBM3, SATB2, ANLN, and CNDP1, potentially involved in human cancers, were selected and antibodies to several non-overlapping epitopes were generated and subsequently validated by Western blot, immunohistochemistry, and immunofluorescence. For all four proteins, a dramatic difference in functionality could be observed for these monospecific antibodies directed to the different epitopes.

Edge dynamics in a quantum spin Hall state: effects from Rashba spin-orbit interaction.

We analyze the dynamics of the helical edge modes of a quantum spin Hall state in the presence of a spatially nonuniform Rashba spin-orbit (SO) interaction. A randomly fluctuating Rashba SO coupling is found to open a scattering channel which causes localization of the edge modes for a weakly screened electron-electron (e-e) interaction. A periodic modulation of the SO coupling, with a wave number commensurate with the Fermi momentum, makes the edge insulating already at intermediate strengths of the e-e interaction.

Exploring epitopes of antibodies toward the human tryptophanyl-tRNA synthetase.

There is a need to characterize the epitopes of affinity reagents to develop high quality affinity reagents for research, diagnostics and therapy. Here, we describe the analysis of epitopes of antibodies generated toward human tryptophanyl-tRNA synthetase (WARS) using both combinatorial bacterial display and suspension bead array. The bacterial display revealed that the polyclonal antibody binds to three separate epitopes and peptide scanning using 15-mers revealed binding to a 13 amino acid consensus sequence (ELINRIERATGQR).

Tunneling between edge states in a quantum spin Hall system.

We analyze a quantum spin Hall device with a point contact connecting two of its edges. The contact supports a net spin tunneling current that can be probed experimentally via a two-terminal resistance measurement. We find that the low-bias tunneling current and the differential conductance exhibit scaling with voltage and temperature that depend nonlinearly on the strength of the electron-electron interaction.

A genome-wide survey of HD-Zip genes in rice and analysis of drought-responsive family members.

The homeodomain leucine zipper (HD-Zip) genes encode transcription factors that have diverse functions in plant development and have often been implicated in stress adaptation. The HD-Zip genes are the most abundant group of homeobox (HB) genes in plants and do not occur in other eukaryotes. This paper describes the complete annotation of the HD-Zip families I, II and III from rice and compares these gene families with Arabidopsis in a phylogeny reconstruction.

Functional profiling reveals that only a small number of phytochrome-regulated early-response genes in Arabidopsis are necessary for optimal deetiolation.

In previous time-resolved microarray-based expression profiling, we identified 32 genes encoding putative transcription factors, signaling components, and unknown proteins that are rapidly and robustly induced by phytochrome (phy)-mediated light signals. Postulating that they are the most likely to be direct targets of phy signaling and to function in the primary phy regulatory circuitry, we examined the impact of targeted mutations in these genes on the phy-induced seedling deetiolation process in Arabidopsis thaliana. Using light-imposed concomitant inhibition of hypocotyl and stimulation of cotyledon growth as diagnostic criteria for normal deetiolation, we identified three major mutant response categories.

A homeodomain leucine zipper gene from Craterostigma plantagineum regulates abscisic acid responsive gene expression and physiological responses.

A subset of homeodomain leucine zipper proteins (HDZip) play a role in regulating adaptation responses including developmental adjustment to environmental cues in plants. Here we report the structural and functional characterisation of a dehydration responsive nuclear-targeted HDZip transcriptional regulator, CpHB-7. DNA-protein interaction studies suggest that CDeT6-19, a known ABA and dehydration responsive dehydrin gene, is a potential target gene of CpHB-7 in the desiccation-tolerant plant Craterostigma plantagineum.

Entanglement scaling in the one-dimensional Hubbard model at criticality.

We derive exact expressions for the local entanglement entropy epsilon in the ground state of the one-dimensional Hubbard model at a quantum phase transition driven by a change in magnetic field h or chemical potential mu. The leading divergences of delta epsilon/delta h and delta epsilon/delta mu are shown to be directly related to those of the zero-temperature spin and charge susceptibilities. Logarithmic corrections to scaling signal a change in the number of local states accessible to the system as it undergoes the transition.

Homeodomain leucine zipper class I genes in Arabidopsis. Expression patterns and phylogenetic relationships.

Members of the homeodomain leucine zipper (HDZip) family of transcription factors are present in a wide range of plants, from mosses to higher plants, but not in other eukaryotes. The HDZip genes act in developmental processes, including vascular tissue and trichome development, and several of them have been suggested to be involved in the mediation of external signals to regulate plant growth. The Arabidopsis (Arabidopsis thaliana) genome contains 47 HDZip genes, which, based on sequence criteria, have been grouped into four different classes: HDZip I to IV.

Measuring Luttinger liquid correlations from charge fluctuations in a nanoscale structure.

We suggest an experiment to study Luttinger liquid behavior in a one-dimensional nanostructure, avoiding the usual complications associated with transport measurements. The proposed setup consists of a quantum box, biased by a gate voltage, and side coupled to a quantum wire by a point contact. Close to the degeneracy points of the Coulomb blockaded box, and in the presence of a magnetic field sufficiently strong to spin polarize the electrons, the setup can be described as a Luttinger liquid interacting with an effective Kondo impurity.

The Arabidopsis thaliana homeobox gene ATHB5 is a potential regulator of abscisic acid responsiveness in developing seedlings.

ATHB5 is a member of the homeodomain-leucine zipper (HDZip) transcription factor gene family of Arabidopsis thaliana. In this report we show that increased expression levels of ATHB5 in transgenic Arabidopsis plants cause an enhanced sensitivity to the inhibitory effect of abscisic acid (ABA) on seed germination and seedling growth. Consistent with this finding we demonstrate in northern blot experiments that the ABA-responsive gene RAB18 is hyperinduced by ABA in transgenic overexpressor lines as compared to the wild type.