Publications by authors named "Henrik Christian Bidstrup Leffers"
Article Synopsis
- The study aimed to evaluate the effectiveness and safety of abatacept and tofacitinib in treating sarcoidosis patients who were unresponsive to previous treatments.
- A total of 41 patients were treated with abatacept, while 12 received tofacitinib, with most tofacitinib patients having prior abatacept treatment.
- After 6 months, both treatments showed high drug survival rates (90% for abatacept, 89% for tofacitinib) and significant responder rates (71% and 67% respectively), indicating they are safe and effective options for patients with persistent symptoms.
Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestations: A Danish genome-wide association study.
Joint Bone Spine
July 2022
Objectives: Cardiovascular autonomic neuropathy (CAN) may affect the clinical course of SLE leading to reduced quality of life. CAN is assessed by heart rate variability (HRV) measures and cardiovascular autonomic reflex tests (CARTs). In patients with SLE, we aimed to determine the characteristics of CAN and if CAN associates with health-related quality of life (HRQoL).
View Article and Find Full Text PDFObjectives: SLE displays large clinical heterogeneity that beyond genetic factors may be determined by environmental exposures. In this Danish nationwide study, we aimed to determine if clinical subsets of SLE were associated with smoking history.
Methods: At each of six participating centres, incident or prevalent inpatients and outpatients with SLE were consecutively included.
Systemic lupus erythematosus (SLE) is a systemic inflammatory autoimmune disease characterized by a broad spectrum of clinical and serological manifestations. This may reflect a complex and multifactorial etiology involving several identified genetic and environmental factors, though not explaining the full risk of SLE. Established SLE risk genotypes are either very rare or with modest effect sizes and twin studies indicate that other factors besides genetics must be operative in SLE etiology.
View Article and Find Full Text PDF