Impaired cholinergic integrity of the colon and pancreas in dementia with Lewy bodies.

Dementia with Lewy bodies is characterized by a high burden of autonomic dysfunction and Lewy pathology in peripheral organs and components of the sympathetic and parasympathetic nervous system. Parasympathetic terminals may be quantified with 18F-fluoroetoxybenzovesamicol, a PET tracer that binds to the vesicular acetylcholine transporter in cholinergic presynaptic terminals. Parasympathetic imaging may be useful for diagnostics, improving our understanding of autonomic dysfunction and for clarifying the spatiotemporal relationship of neuronal degeneration in prodromal disease.

[Not Available].

The number of people with dementia is expected to increase both in Denmark and globally. As dementia progresses dyphagia often develop, and increase risk of aspiration. Enteral nutrition via nasogatric and percutaneus feeding tube have several complications, and does not reduce the risk of pneumonia, hospital readmission, or decrease mortality.

Diagnostic Cut-offs for CSF β-amyloid and tau proteins in a Danish dementia clinic.

Background: Analysis of beta-amyloid 1-42 (Aβ42), total tau (t-tau) and phosphorylated-tau 181 (p-tau) in the cerebrospinal fluid (CSF) is often performed as a part of the diagnostic work-up in case of suspected Alzheimer's dementia (AD). Unfortunately, studies on optimal CSF biomarker cut-offs in a real-world clinical setting are scarce.

Methods: We retrospectively evaluated the biomarker levels of 264 consecutive patients referred to our dementia clinic.

Reduced Synaptic Density in Patients with Lewy Body Dementia: An [ C]UCB-J PET Imaging Study.

Background: Patients with Parkinson's disease (PD) often develop dementia, but the underlying substrate is incompletely understood. Generalized synaptic degeneration may contribute to dysfunction and cognitive decline in Lewy body dementias, but in vivo evidence is lacking.

Objective: The objective of this study was to assess the density of synapses in non-demented PD (nPD) subjects (N = 21), patients with PD-dementia or Dementia with Lewy bodies (DLB) (N = 13), and age-matched healthy controls (N = 15).

[Phenotypic variability in a family with genetically verified familial hemiplegic migraine type 2].

After playing handball, a 13-year-old girl developed a comatose condition during 7-10 days with hemiparesis and aphasia. From age three to nine she was treated for partial epilepsy. She never had symptoms of migraine.

Early evoked pain or dysesthesia is a predictor of central poststroke pain.

Central poststroke pain (CPSP) is a central neuropathic pain condition caused by a cerebrovascular lesion affecting the central somatosensory nervous system. Once developed, CPSP is difficult to treat, so there is an interest in identifying stroke patients at risk for the development of CPSP. This study examined if sensory abnormalities, including evoked dysesthesia, allodynia, or hyperalgesia to static and dynamic touch, cold, and pinprick, at stroke onset are a predictor for the development of CPSP.

Development of persistent headache following stroke: a 3-year follow-up.

Background: Headache following stroke has been described in previous studies with an incidence of 23%-54%, but a clear description of headache developing after stroke onset is still lacking. The aim of this study was to determine the incidence and characteristics of persistent novel headache after stroke and to describe the use of medication, including dipyridamole.

Methods: As a follow-up to a prospective study, a standardized questionnaire about characteristics of novel headache and medication use was sent out to surviving patients three years after their stroke.

Pain following stroke: a population-based follow-up study.

Background And Purpose: Chronic pain is increasingly recognized as a consequence of stroke. This study aimed to describe the prevalence and pain types of new onset chronic pain ("novel pain") in patients with stroke compared with a randomly selected reference group from the general population and to identify factors associated with pain development in stroke patients.

Methods: In a population-based follow-up design, development of chronic pain after stroke was assessed by a questionnaire sent to consecutive stroke patients, registered in a Danish national stroke database, two years after their stroke.

Central poststroke pain: a population-based study.

Central poststroke pain (CPSP) is a specific pain condition arising as a direct consequence of a cerebrovascular lesion. There is limited knowledge about the epidemiology and clinical characteristics of this often neglected but important consequence of stroke. In this population-based study, a questionnaire was sent out to all (n=964) stroke patients identified through the Danish National Indicator Project Stroke Database in Aarhus County, Denmark, between March 2004 and February 2005.

Central post-stroke pain: clinical characteristics, pathophysiology, and management.

Central post-stroke pain (CPSP) is a neuropathic pain syndrome that can occur after a cerebrovascular accident. This syndrome is characterised by pain and sensory abnormalities in the body parts that correspond to the brain territory that has been injured by the cerebrovascular lesion. The presence of sensory loss and signs of hypersensitivity in the painful area in patients with CPSP might indicate the dual combination of deafferentation and the subsequent development of neuronal hyperexcitability.

[Poststroke pain].

Pain following stroke is a common but often neglected problem. Headache is present in about one fourth of patients in the acute phase. Later, chronic musculoskeletal pain including shoulder pain may be present, partly due to muscle weakness, posture and stiffness.

[Child neglect in the county of Copenhagen. Changing incidence?].

Introduction: The aim of the study was to evaluate the incidence of physical violence, neglect, and sexual abuse of children as reported to the local authorities in the County of Copenhagen during the year 1998, and compare it with a similar study conducted in 1993.

Material And Methods: A questionnaire was posted to the local authorities of the 18 districts in the county. They were asked how many new, verified, and suspected cases of physical, emotional, and sexual abuse had come to their attention in 1998.