Publications by authors named "Henrietta Norman"
Article Synopsis
- - SMARTEST is a clinical trial comparing the effectiveness of dapagliflozin and metformin in early-stage type 2 diabetes, focusing on microvascular complications tracked by the Swedish National Diabetes Register (NDR).
- - The study validated the accuracy of microvascular complication data from the NDR by comparing it with electronic health records (EHRs) from 276 participants over three years, finding a high agreement rate across various health indicators.
- - Results showed strong correlations between the NDR and EHR data, supporting the reliability of national health care registries for collecting endpoint data in clinical trials like SMARTEST.
Myeloperoxidase (MPO) is a prime candidate for promoting oxidative stress during inflammation. This abundant enzyme of neutrophils uses hydrogen peroxide to oxidize chloride to highly reactive and toxic chlorine bleach. We have identified 2-thioxanthines as potent mechanism-based inactivators of MPO.
View Article and Find Full Text PDFThe presence of beta-amyloid plaques in brain is a hallmark of Alzheimer's disease (AD) and serves as a biomarker for confirmation of diagnosis postmortem. Positron emission tomography (PET) radioligands such as Pittsburgh compound B ([(11)C]-2-(3-fluoro-4-methylamino-phenyl)-benzothiazol-6-ol) (PIB) binds selectively to beta-amyloid and are promising new tools supporting the clinical diagnoses of AD. In addition, such methodology may be useful for evaluation of new drugs aiming at reduction of amyloid plaque load.
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