Publications by authors named "Henri Decauchy"
Article Synopsis
- Cold piezoelectric plasma (CPP) is a new cancer treatment method that can lead to cancer cell death and the development of portable treatment devices, specifically targeting cholangiocarcinoma (CCA).
- In vitro experiments use two types of CPP devices, corona discharge (Pz-CD) and dielectric barrier discharge (Pz-DBD), with Pz-CD delivering more power but both generating significant reactive species.
- CPP shows immediate effects like remodeling of the actin cytoskeleton and long-term effects through activation of the DNA damage response pathway, suggesting its potential as an effective antitumor therapy.
Through the last decade, cold atmospheric plasma (CAP) has emerged as an innovative therapeutic option for cancer treatment. Recently, we have set up a potentially safe atmospheric pressure plasma jet device that displays antitumoral properties in a preclinical model of cholangiocarcinoma (CCA), a rare and very aggressive cancer emerging from the biliary tree with few efficient treatments. In the present study, we aimed at deciphering the molecular mechanisms underlying the antitumor effects of CAP towards CCA in both an in vivo and in vitro context.
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