Fusion of PCA and ICA in Statistical Subset Analysis for Speech Emotion Recognition.

Speech emotion recognition is key to many fields, including human-computer interaction, healthcare, and intelligent assistance. While acoustic features extracted from human speech are essential for this task, not all of them contribute to emotion recognition effectively. Thus, reduced numbers of features are required within successful emotion recognition models.

Fostering Trust in Public Health Messaging: Tailoring Communication for Rural Parents.

Purpose: As pandemic-related mistrust of public health recommendations in rural communities may compound gaps in pediatric immunizations, our team explored parents' perceptions of trustworthiness in messaging.

Design: Qualitative study using 4 virtual focus groups.

Setting: Rural Wisconsin.

Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy.

Protein Tyrosine Phosphatase 1B (PTP1B) is a negative regulator of leptin signaling whose disruption protects against diet-induced obesity in mice. We investigated whether structural characterization of human PTP1B variant proteins might reveal precise mechanisms to target for weight loss therapy. We selected 12 rare variants for functional characterization from exomes from 997 people with persistent thinness and 200,000 people from UK Biobank.

Loss of transient receptor potential channel 5 causes obesity and postpartum depression.

Hypothalamic neural circuits regulate instinctive behaviors such as food seeking, the fight/flight response, socialization, and maternal care. Here, we identified microdeletions on chromosome Xq23 disrupting the brain-expressed transient receptor potential (TRP) channel 5 (TRPC5). This family of channels detects sensory stimuli and converts them into electrical signals interpretable by the brain.

Neural circuits expressing the serotonin 2C receptor regulate memory in mice and humans.

Declined memory is a hallmark of Alzheimer's disease (AD). Experiments in rodents and human postmortem studies suggest that serotonin (5-hydroxytryptamine, 5-HT) plays a role in memory, but the underlying mechanisms are unknown. Here, we investigate the role of 5-HT 2C receptor (5-HTR) in regulating memory.

Carbon and nitrogen dynamics in agricultural soil after application of cattle manure and eastern redcedar wood chips.

Uncontrolled proliferation of eastern redcedar tree (Juniperus virginiana) in the Midwest United States requires new alternatives for utilization of waste wood, such as mulching, that promotes efficient tree management by landowners. Similarly, efficient use of manure from animal feeding operations in cropping systems can reduce negative environmental impacts and increase cropland productivity. The objectives of this study were to quantify the nitrogen (N) and carbon (C) decomposition rates, availability, and effects on soil chemical properties of eastern redcedar wood chips (WC), cattle manure (CM), and the combination of cattle manure and wood chips (MW).

Inactive nurses' willingness to return to active nursing during the COVID-19 pandemic: A qualitative study.

Aims: To investigate factors that influence the willingness of inactive nurses to return to nursing in a crisis situation and to identify aspects that need to be considered with regard to a possible deployment.

Design: A deductive and inductive qualitative content analysis of semi-structured focus group interviews.

Methods: Semi-structured focus group interviews with inactive or marginally employed nurses, nurses who have been inactive for some time and nursing home managers in October and November 2021.

Explaining the U.S. rural disadvantage in COVID-19 case and death rates during the Delta-Omicron surge: The role of politics, vaccinations, population health, and social determinants.

The Delta-Omicron wave of the COVID-19 pandemic (Wave 4) in the United States occurred in Fall of 2021 through Spring of 2022. Although vaccinations were widely available, this was the deadliest period to date in the U.S.

Statistical parametric and non-parametric control charts for monitoring residential water consumption.

The adoption of strategies for monitoring water consumption is essential for water resources management, contributing to the promotion of the sustainability in the water sector. Statistical process control (SPC) charts, which are widely used in the industrial sector, are statistical methods developed to improve the quality of products and processes. The application of this method has reached other areas over the last decades and has recently been identified as an option for environmental monitoring.

Accelerated waning of the humoral response to COVID-19 vaccines in obesity.

Obesity is associated with an increased risk of severe Coronavirus Disease 2019 (COVID-19) infection and mortality. COVID-19 vaccines reduce the risk of serious COVID-19 outcomes; however, their effectiveness in people with obesity is incompletely understood. We studied the relationship among body mass index (BMI), hospitalization and mortality due to COVID-19 among 3.

Solid waste management and infestation interconnections: A regression tree application.

Public health is at the core of all environmental and anthropic impacts. Urban and territorial planners should include public health concerns in their plans. Basic sanitation infrastructure is essential to maintaining public health and social and economic development.

A rare human variant that disrupts GPR10 signalling causes weight gain in mice.

Disruption of brain-expressed G protein-coupled receptor-10 (GPR10) causes obesity in animals. Here, we identify multiple rare variants in GPR10 in people with severe obesity and in normal weight controls. These variants impair ligand binding and G protein-dependent signalling in cells.

Intramedullary Single-Kirschner-Wire Fixation in Displaced Fractures of the Fifth Metacarpal Neck (Boxer's Fracture).

Unlabelled: The fracture of the fifth metacarpal neck (also called a boxer's fracture) is the most common fracture of the hand. Displaced fractures often result in volar angulation of the metacarpal head, shortening, and residual malrotation. The present video article demonstrates the steps of performing intramedullary single-Kirschner-wire fixation of the fifth metacarpal neck, with the aim of the procedure being to achieve a closed reduction and internal stabilization of such a fracture.

The Impact of Acute Nutritional Interventions on the Plasma Proteome.

Context: Humans respond profoundly to changes in diet, while nutrition and environment have a great impact on population health. It is therefore important to deeply characterize the human nutritional responses.

Objective: Endocrine parameters and the metabolome of human plasma are rapidly responding to acute nutritional interventions such as caloric restriction or a glucose challenge.

Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior.

Serotonin reuptake inhibitors and receptor agonists are used to treat obesity, anxiety and depression. Here we studied the role of the serotonin 2C receptor (5-HTR) in weight regulation and behavior. Using exome sequencing of 2,548 people with severe obesity and 1,117 control individuals without obesity, we identified 13 rare variants in the gene encoding 5-HTR (HTR2C) in 19 unrelated people (3 males and 16 females).

Water demand profile before and during COVID-19 pandemic in a Brazilian social housing complex.

The COVID-19 pandemic has changed the way resources are consumed around the world. The relationship between the pandemic and water consumption has important implications for the management of water use and must be evaluated in depth. The main goal of this research paper is to establish a comparison between pre-pandemic and pandemic water consumption profiles for 14 social-housing buildings located in Joinville, Southern Brazil.

Optimizing home-based long-term intensive care for neurological patients with neurorehabilitation outreach teams - protocol of a multicenter, parallel-group randomized controlled trial (OptiNIV-Study).

Background: Even with high standards of acute care and neurological early rehabilitation (NER) a substantial number of patients with neurological conditions still need mechanical ventilation and/or airway protection by tracheal cannulas when discharged and hence home-based specialised intensive care nursing (HSICN). It may be possible to improve the home care situation with structured specialized long-term neurorehabilitation support and following up patients with neurorehabilitation teams. Consequently, more people might recover over an extended period to a degree that they were no longer dependent on HSICN.

To come back or not to come back during the coronavirus crisis-A cross-sectional online survey of inactive nurses.

Aims: To examine whether inactive nurses are willing to return to nursing during the COVID-19 pandemic, the reasons for or against their decision and further, possibly relevant factors.

Design: Cross-sectional online survey.

Methods: We developed a questionnaire, addressing registration, professional experiences, anticipations, and internal and external factors that might affect the decision of inactive nurses to return to nursing during the pandemic.

[Qualification requirements for the re-delegation of medical activities to nursing professionals (with extended competencies)].

Background: For many years, the redistribution of tasks and thus a transfer of medical activities to nursing professionals with extended competencies has been discussed in Germany and is currently being regulated by the federal government.

Objectives: The aim of this study was to record the opinions of GPs and nurses on the qualification requirements for possible delegable and substitutable medical activities to nurses using the example of outpatient dementia care.

Method: In the context of a quantitative survey, the qualification requirements for the delegation of 30 different activities to nurses were collected from primary care physicians and nurses.

[Transfer of Physicians' Tasks to Nurses in the Care of People with Dementia].

The Aim Of The Study: A transfer of medical activities to nurses and thus the redistribution of tasks has been discussed for almost 15 years. A legal base for model projects has been enacted. However, clearly defined tasks for substitution are still lacking.

Visualization of sympathetic neural innervation in human white adipose tissue.

Obesity, defined as an excess of adipose tissue that adversely affects health, is a major cause of morbidity and mortality. However, to date, understanding the structure and function of human adipose tissue has been limited by the inability to visualize cellular components due to the innate structure of adipocytes, which are characterized by large lipid droplets. Combining the iDISCO and the CUBIC protocols for whole tissue staining and optical clearing, we developed a protocol to enable immunostaining and clearing of human subcutaneous white adipose tissue (WAT) obtained from individuals with severe obesity.