From silicon to silica: a green chemistry approach for hollow sphere nanoparticle formation.

Herein we report on an environmentally friendly and scalable production route for hollow silica spheres (HSSs). The process is based on close to 100% conversion of non-crystalline solid Si nanoparticles ( = 40 ± 9 nm) in mild alkaline solutions (pH ≤ 9.0) at ambient temperature.

Stable "snow lantern-like" aggregates of silicon nanoparticles suitable as a drug delivery platform.

Nanomedicine is a growing field where development of novel organic and inorganic materials is essential to meet the complex requirements for drug delivery. This includes biocompatibility, suitability for surface modifications, biodegradability, and stability sufficient to carry a drug payload through various tissues for the desired timespan. Porous silicon nanoparticles (pSi NP) are shown to have several beneficial traits in drug delivery in addition to a porous structure to maximize drug loading.

Molecular Hydrogen Therapy-A Review on Clinical Studies and Outcomes.

With its antioxidant properties, hydrogen gas (H) has been evaluated in vitro, in animal studies and in human studies for a broad range of therapeutic indications. A simple search of "hydrogen gas" in various medical databases resulted in more than 2000 publications related to hydrogen gas as a potential new drug substance. A parallel search in clinical trial registers also generated many hits, reflecting the diversity in ongoing clinical trials involving hydrogen therapy.

Silicon nanoparticles for oral administration of molecular hydrogen.

Medical use of hydrogen gas (H) has been given increasing attention over the past 15 years with numerous clinical trials for a variety of indications. The biological activity of H includes antioxidant properties and thereby the ability to neutralize damaging reactive oxygen species (ROS). Administration of hydrogen as a medical gas is limited by the poor water solubility and by the flammability of H in air.