Publications by authors named "Hennessey E"

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  • Solar lentigo is a common skin condition that can impact individuals of any age or ethnicity.
  • A study evaluated the effectiveness of combining two treatments, BBL® HERO (a pulsed light device) and MOXI (a nonablative laser), for reducing these brown spots on the face during a single session.
  • Results showed significant improvement in the appearance of solar lentigines in nine patients, with some experiencing continued benefits nearly 20 months after treatment.
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  • Anti-β-amyloid immunotherapy with lecanemab shows promise for Alzheimer’s patients, particularly those with Down syndrome, who develop Alzheimer-like brain changes by their 40s.
  • A study analyzed postmortem brain tissue from 15 individuals with Down syndrome to assess how well lecanemab binds to amyloid plaques and blood vessels in the brain.
  • Results indicated that while lecanemab effectively binds to amyloid plaques, it also binds significantly to blood vessels, raising safety concerns and highlighting the need for careful clinical trials in this population.
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Background: Prenatal glucocorticoids are one of the most widely proposed prenatal programming mechanisms, yet few studies exist that measure fetal cortisol via neonatal hair. Neonatal hair provides a window into the fetal experience and represents cortisol accumulation in the third trimester of pregnancy. In the current study, we test the links between two types of anxiety over the course of gestation (pregnancy-related anxiety and general anxiety) with neonatal hair cortisol.

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  • Mutations in ABCA3, a crucial transporter for lung surfactant balance, are the leading genetic cause of childhood interstitial lung disease (chILD), but effective treatments are limited due to a lack of understanding of how these mutations cause disease.
  • Researchers generated induced pluripotent stem cells (iPSCs) from affected patients with ABCA3 mutations to create alveolar type II epithelial cells (AEC2s) for in vitro modeling, which revealed decreased surfactant secretion and unexpected abnormal characteristics in mutant cells.
  • Using ABCA3:GFP fusion reporters, the study quantified how different ABCA3 mutations affect lamellar body size and protein trafficking, providing insights into the
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  • Prenatal maternal anxiety, particularly pregnancy-related anxiety, can negatively impact how infants focus on emotional faces, which is crucial for their social and emotional development.
  • A study involving 86 mothers showed that higher pregnancy-related anxiety predicted less attention from infants towards emotional faces compared to neutral ones.
  • Although the study found significant correlations, it can't establish a cause-and-effect relationship, highlighting the need for further research on the implications of maternal anxiety on child development.
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Limited studies assess the efficacy of vitamin K administration in patients with chronic liver disease (CLD). However, vitamin K is commonly used to treat elevations in international normalized ratio (INR) in these patients with the intended benefit of reducing bleeding risk. This retrospective, single-center cohort study aimed to evaluate the impact of vitamin K administration on INR in patients with CLD.

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Importance: Prenatal depression is prevalent with negative consequences for both the mother and developing fetus. Brief, effective, and safe interventions to reduce depression during pregnancy are needed.

Objective: To evaluate depression improvement (symptoms and diagnosis) among pregnant individuals from diverse backgrounds randomized to brief interpersonal psychotherapy (IPT) vs enhanced usual care (EUC).

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Biased attention toward affective cues often cooccurs with the emergence and maintenance of internalizing disorders. However, few studies have assessed whether affect-biased attention in infancy relates to early indicators of psychopathological risk, such as negative affectivity. The current study evaluates whether negative affectivity relates to affect-biased attention in 6-month-old infants.

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Strategies for the intraoperative ventilator management of the critically ill patient focus on parameters used for lung protective ventilation with acute respiratory distress syndrome, preventing or limiting the deleterious effects of mechanical ventilation, and optimizing anesthetic and surgical conditions to limit postoperative pulmonary complications for patients at risk. Patient conditions such as obesity, sepsis, the need for laparoscopic surgery, or one-lung ventilation may benefit from intraoperative lung protective ventilation strategies. Anesthesiologists can use risk evaluation and prediction tools, monitor advanced physiologic targets, and incorporate new innovative monitoring techniques to develop an individualized approach for patients.

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Background: A large body of research supports the deleterious effects of adverse childhood experiences (ACEs) on disease susceptibility and health for both the exposed individual and the next generation. It is likely that there is an intergenerational transmission of risk from mother to child; however, the mechanisms through which such risk is conferred remain unknown. The current study evaluated the association between maternal ACEs, neonatal brain development of the amygdala and hippocampus, and later infant negative emotionality at six months of age.

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Artificial intelligence in veterinary medicine is an emerging field. Machine learning, a subfield of artificial intelligence, allows computer programs to analyze large imaging datasets and learn to perform tasks relevant to veterinary diagnostic imaging. This review summarizes the small, yet growing body of artificial intelligence literature in veterinary imaging, provides necessary background to understand these papers, and provides author commentary on the state of the field.

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Hypaxial muscle abscess is an important differential in dogs presenting for abdominal or back pain, lameness, and nonspecific signs like fever, lethargy, and hyporexia. It can occur concurrently with intrathoracic disease such as pyothorax secondary to migrating vegetal foreign material. Twelve dogs that underwent CT of the lumbar spine or abdomen and had a diagnosed hypaxial abscess on surgical and/or microbiological examination were included in this retrospective, descriptive case series.

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Background: Opioid-induced constipation (OIC) treatment guidelines recommend over-the-counter laxatives as first-line therapy, followed by treatment with a peripherally-acting mu-opioid receptor antagonist (PAMORA) in refractory patients.

Objective: To evaluate the ability of a pharmacist-driven OIC protocol to promote increased scheduled laxative use prior to escalation to PAMORA therapy.

Methods: This retrospective, single-center cohort study evaluated patients 2 years pre- and post-protocol implementation.

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The purpose of the current project was to assess missed opportunities to identify metabolic syndrome in patients treated with second-generation antipsychotic medication in a community hospital's inpatient psychiatric unit between January 1 and December 31, 2020. Data on demographics, metabolic syndrome risk factors, body mass index, medications, related diagnoses, and primary care providers (PCPs) were collected via retrospective chart review of 194 patients. This project used a nonexperimental design and heterogenous nonrandom convenience sample.

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It is well-recognized that increasingly polarized American partisans subscribe to sharply diverging worldviews. Can partisanship influence Americans to view the world around them differently from one another? In the current research, we explored partisans' recollections of objective events that occurred during identical footage of a real protest. All participants viewed the same 87-second compilation of footage from a Women's March protest.

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Introduction: Research on risk factors for prenatal depression is critical to improve the understanding, prevention, and treatment of women's psychopathology. The current study examines the relation between experiences of racial discrimination and trajectories of depression symptoms over the course of pregnancy.

Method: Participants completed standardized measures regarding symptoms of depression at four timepoints during pregnancy and reported on experiences of racial discrimination at one timepoint.

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Nicotinamide mononucleotide adenylyltransferase 1 (NMNAT1) is required for nuclear nicotinamide adenine mononucleotide (NAD+) biosynthesis in all nucleated cells, and despite its functional ubiquity, mutations in this gene lead to an isolated retinal degeneration. The mechanisms underlying how mutant NMNAT1 causes disease are not well understood, nor is the reason why the pathology is confined to the retina. Using a mouse model of NMNAT1-associated retinal degeneration that harbors the p.

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Background: The COVID-19 pandemic has been uniquely challenging for pregnant and postpartum women. Uncontrollable stress amplifies risk for maternal depression and anxiety, which are linked to adverse mother and child outcomes. This study examined change in internalizing symptoms from before to during the COVID-19 pandemic among pregnant and postpartum women longitudinally, and investigated moderation by loneliness and other contextual risk factors.

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Migraine headache treatment is quickly evolving. There have been three new acute migraine treatment options (i.e.

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Chronic stress during childhood negatively impacts cognition and physical and mental health. Exposure to stressors over time can cause hypothalamic-pituitary-adrenal (HPA) axis dysregulation, leading to abnormal stress hormone levels, which can be reflected in hair cortisol concentration (HCC) and hair dehydroepiandrosterone (DHEA) concentration. Although the use of HCC and DHEA to measure chronic stress in children is increasing, their effects on cognition (as indexed by executive function) remain unexplored.

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No treatment is available for nicotinamide mononucleotide adenylyltransferase 1 ()-associated retinal degeneration, an inherited disease that leads to severe vision loss early in life. Although the causative gene, , plays an essential role in nuclear nicotinamide adenine dinucleotide (NAD) metabolism in tissues throughout the body, -associated disease is isolated to the retina. Since this condition is recessive, supplementing the retina with a normal copy of should protect vulnerable cells from disease progression.

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The success of base editors for the study and treatment of genetic diseases depends on the ability to deliver them in vivo to the relevant cell types. Delivery via adeno-associated viruses (AAVs) is limited by AAV packaging capacity, which precludes the use of full-length base editors. Here, we report the application of dual AAVs for the delivery of split cytosine and adenine base editors that are then reconstituted by trans-splicing inteins.

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Transitions of care (TOC) points are those where patient outcomes can be affected, especially patients at high risk for medication errors. Pharmacist-led postdischarge telephone counseling positively affects patient outcomes, though challenges exist relating to successful patient contact. The objective of this study was to develop and evaluate a discharge education service bridging the inpatient and outpatient setting to increase successful patient contact points during the TOC process from hospital to home.

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Purpose: Inpatient hyperglycemia is associated with poor outcomes. Existing research assessing inpatient hyperglycemia protocols has shown improvements in average blood glucose levels with inconsistent results regarding rates of hypoglycemia and hyperglycemia. The objective of this study was to evaluate the impact of an inpatient hyperglycemia protocol on glycemic control.

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