Volume expansion mitigates Shiga toxin-producing E. coli-hemolytic uremic syndrome in children.

Background: Shiga toxin-producing E. coli-hemolytic uremic syndrome (STEC-HUS) is associated with high morbidity and relevant mortality. Previous small studies showed that volume expansion could improve the course and outcome of STEC-HUS.

Mucoid degeneration of the anterior cruciate ligament corrected with autograft reconstruction.

The anterior cruciate ligament (ACL) is the most frequently injured knee ligament, typically in non-contact athletic injuries in young adults. Mucoid degeneration of the ACL (ACL-MD) is an uncommon ACL pathology in which glycosaminoglycans deposition within the collagenous bundles leads to hypertrophy, loss of full knee flexion and knee pain without instability. ACL-MD usually presents in individuals over 40 years with sudden-onset knee pain after minimal trauma or as an incidental MRI finding.

Postnatal Repair of Open Neural Tube Defects: A Single Center with 90-Month Interdisciplinary Follow-Up.

After publication of the Management of Myelomeningocele Study (MOMS) there is confusion regarding which treatment of open neural tube defects (NTD) is best. We report our results of postnatally repaired open NTDs born between 2007-2018 ( = 36) in critical reflection of the MOMS study. Neurosurgical, orthopedic, and urologic data were assessed.

Professional Nursing Values in Men: An NPVS-R Instrument Validation Study.

Background And Purpose: Although the Nurses Professional Values Scale-Revised (NPVS-R) has been validated in predominantly female samples, this instrument has not been validated with adequate samples of men. The purpose of the study was to assess the reliability and validity of the NPVS-R in a sample of male nurses and nursing students.

Methods: Psychometric testing was performed, using principal component analysis (PCA), on a convenience sample of 329 men in nursing from the United States.

Current Perceptions: The DNP-PhD Divide.

Background: Doctor of Nursing Practice (DNP) and PhD degrees are terminal degrees in nursing, yet they differ in preparation and intended purpose. Perceptions of DNP- and PhD-prepared faculty, staff, and administrators regarding DNP/PhD teaching roles, research expectations, and attitudes toward collaboration are poorly understood.

Objective: This mixed-method study sought to identify current perceptions related to collaboration and utilization of DNP- and PhD-prepared faculty, staff, and administrators.

Bilateral Inferior Angle Ossicles of the Scapula: Pain Generators in a Young Woman: A Case Report.

Case: We present the case of a 16-year-old woman with refractory shoulder pain despite nonoperative treatment. The only shoulder pathology that was noted on advanced imaging was an unfused ossicle on the inferior angle of each scapula. She was successfully treated with simple excision bilaterally; as demonstrated by the shoulder scores, there was substantial improvement.

Effects of latex avoidance on latex sensitization, atopy and allergic diseases in patients with spina bifida.

Background: Ten years ago, avoidance measures such as the performance of latex-free operations were implemented in children with spina bifida. Since then, latex sensitization and latex allergy have decreased in this high-risk group.

Objective: To study the effect of primary latex-free prophylaxis on the prevalence of allergic diseases and atopy as a marker for sensitization spreading in children with spina bifida.

Propiverine vs oxybutynin for treating neurogenic detrusor overactivity in children and adolescents: results of a multicentre observational cohort study.

Objective: To compare, in a retrospective observational cohort study, the efficacy, tolerability, safety and clinical effectiveness of propiverine and oxybutynin in children and adolescents with neurogenic detrusor overactivity (NDO).

Patients And Methods: In all, 255 children and adolescents (aged 1-18 years) with NDO (199 myelomeningocele, 46 spinal cord injury, 10 other diagnoses) were enrolled at 14 study centres. To evaluate the efficacy of propiverine and oxybutynin, urodynamic and clinical variables were assessed before and after at least 12 month of the antimuscarinic agents administered at variable doses.

Recalcitrant patellar tendinosis in elite athletes: surgical treatment in conjunction with aggressive postoperative rehabilitation.

Background: Recalcitrant patellar tendinosis is difficult to treat, and results are varied.

Hypothesis: Surgical removal of necrotic tissue, surgical stimulation of remaining tendon, and aggressive and specific rehabilitation after patellar tendonectomy will allow athletes to return to sports.

Study Design: Case series; Level of evidence, 4.

Urodynamic effects of propiverine hydrochloride in children with neurogenic detrusor overactivity: a prospective analysis.

Objectives: To evaluate prospectively the efficacy and tolerability of propiverine for treating neurogenic detrusor overactivity (NDO) in children.

Patients And Methods: Twenty children (mean age 8.9 years; median 5.

The Cole midfoot osteotomy: a retrospective review of 11 procedures in 8 patients.

This article presents the results of a retrospective chart and radiographic review of 11 feet (8 patients) that underwent a Cole midfoot osteotomy from February 1998 through October 2000 at the Western Pennsylvania Hospital. The average time to follow-up was 23 months (range, 11 to 29.5 months).

Mycophenolate mofetil-induced reversal of glomerular filtration loss in children with chronic allograft nephropathy.

Background: Mycophenolate mofetil (MMF) has been used for the treatment of chronic allograft nephropathy (CAN) in adults with inconsistent results, but data in children are rare. To evaluate its impact on advanced CAN, we studied changes in glomerular filtration rate (GFR) and the correlation of GFR changes to histology.

Methods: Thirty-six children (13.

Computer-assisted quantification of fibrosis in chronic allograft nephropaty by picosirius red-staining: a new tool for predicting long-term graft function.

Background: Chronic allograft nephropathy (CAN) has become the predominant limiting factor for long-term transplant survival. A cardinal histomorphologic correlate for CAN is interstitial fibrosis. Currently, no method has been established in routine use that reliably quantifies the extent of interstitial fibrosis in renal grafts.

Cytokine single nucleotide polymorphisms and intrarenal gene expression in chronic allograft nephropathy in children.

Background: Single nucleotide polymorphisms (SNPs) have been reported to influence cytokine production. Certain cytokine high producer genotypes have been associated with an increased risk for acute rejection and chronic allograft dysfunction (CAD) after transplantation. Our study evaluates SNP distribution for transforming growth factor-beta1 (TGF-beta1), interleukin-10 (IL-10), and tumor necrosis factor-alpha (TNF-alpha) in pediatric renal transplant recipients and control individuals and correlates them to corresponding intrarenal gene expression.

Total ankle arthroplasty: a historical perspective.

The ideal total ankle prosthesis has yet to be determined, but much has been learned from early experiences in ankle arthroplasty. Modern implants are typically more respectful of anatomic concerns, have found a happy medium of constraint, and have found novel approaches to decrease interface stress. Biologic fixation has improved on cemented results.

The beta2-microglobulin/cystatin C ratio--a potential marker of post-transplant lymphoproliferative disease.

Background: As a consequence of more intensified immunosuppression, post-transplant lymphoproliferative disease (PTLD) is increasingly observed in patients after solid-organ transplantation. Beta2-microglobulin, a low-molecular weight protein (MW 11.8 kDa), is produced by all nucleated cells as part of the HLA complex.

Single centre experience with basiliximab in paediatric renal transplantation.

Background: Introduction of IL-2-receptor antagonists has led to significantly decreasing numbers of acute rejection episodes in renal transplantation in adults. No data are available in paediatric recipients.

Methods: Between 1997 and 2000, 78 renal transplantations were performed in 77 children aged 0.

Hypokalemic salt-losing tubulopathy with chronic renal failure and sensorineural deafness.

Objective: To characterize a rare inherited hypokalemic salt-losing tubulopathy with linkage to chromosome 1p31.

Methods: We conducted a retrospective analysis of the clinical data for 7 patients in whom cosegregation of the disease with chromosome 1p31 had been demonstrated. In addition, in 1 kindred, prenatal diagnosis in the second child was established, allowing a prospective clinical evaluation.

Perioperative management of central diabetes insipidus in kidney transplantation.

Central diabetes insipidus is clinically masked in dialysis patients. We report a 12-year-old girl receiving a living-related donor graft for renal failure from Alport syndrome, in whom a craniopharyngioma had been resected 6 months before transplantation. Pretransplant evaluation had documented central hypothyroidism, growth hormone deficiency, and presumptive hypogonadotropic hypogonadism.

Physeal fractures of the ankle.

Because the distal tibia is the third most common physeal injury, being able to assess and treat such a fracture accurately is a skill worth enhancing. Many factors contribute to the outcome of physeal injuries, but the physician's general knowledge of the physis, ability to order the right diagnostic tests, and classify the fracture can be the determining factors of quality care.

Small-bowel obstruction and perforation. A rare complication of an esophageal stent.

To bridge a malignant stenosis after esophageal cancer recurrence two silicon-coated wall stents were inplanted in a 52-year-old patient within 6 months. Two weeks after the second stent was implanted, clinical examination showed dislocation of the prosthesis. Intraoperatively the two stents were found sticking in the side-to-side jejunostomy of a former Billroth II operation, leading to perforation there.

[Rehn-Delorme operation in pelvic floor insufficiency].

Rehn-Delorme's procedure was introduced as one of a couple of methods to remove rectal prolapse with insufficiency of the pelvic floor. Rehn-Delorme's procedure wasn't well accepted until the last twenty years, when some authors reported good results with low recurrence rate of the prolapse, especially for old people with high risk or otherwise unfit for abdominal surgical procedures. On the German Clinic for Diagnostic during the years 1991-1994 in a therapeutical concept of the conjoint problems "chronic constipation--rectal prolapse-faecal incontinence" 205 patients, aged 20 to 86 years, were operated on with that procedure.

[HIV positive patients in routine surgical practice].

In our daily surgical practice we encounter increasingly HIV-infected and AIDS patients. From January 1 1987 until December 31 1988 119 outpatients and 35 hospitalized patients were treated in the surgical department. They belonged mainly to the known risk groups.