Effects of sea buckthorn and bilberry on serum metabolites differ according to baseline metabolic profiles in overweight women: a randomized crossover trial.

Background: Berries are associated with health benefits. Little is known about the effect of baseline metabolome on the overall metabolic responses to berry intake.

Objective: We studied the effects of berries on serum metabolome.

1H NMR-based metabolic fingerprinting of urine metabolites after consumption of lingonberries (Vaccinium vitis-idaea) with a high-fat meal.

The use of NMR metabolomics in clinical trials is growing; however, reports of postprandial experiments in humans are scarce. The present study investigated whether consumption of lingonberries as a supplement to an oil-rich meal modifies the postprandial fingerprints of human urine. Urine samples were analysed by (1)H NMR, and untargeted multivariate analysis was applied to the data for comprehensive fingerprinting.

Children's hedonic response to berry products: Effect of chemical composition of berries and hTAS2R38 genotype on liking.

The hedonic response of 104 healthy children, recruited from day-care centres and schools, to 12 different berry products with varying content of added sugar was studied. The berries used as ingredients were blackcurrant (Ribes nigrum), sea buckthorn (Hippophaë rhamnoides), bilberry (Vaccinium myrtillus), and lingonberry (Vaccinium vitis-idaea). Another aim of the study was to study the effects of the chemical composition of berries as well as children's hTAS2R38 taste receptor genotypes on liking.

The fiber and/or polyphenols present in lingonberries null the glycemic effect of the sugars present in the berries when consumed together with added glucose in healthy human volunteers.

This study was undertaken on the broad hypothesis that lingonberry (Vaccinium vitis-idaea L.) has potential to reduce postprandial glycemic and lipemic response. More specifically, 2 postprandial crossover studies with healthy normal-weight male subjects were conducted to study the influence of commercial lingonberry powder on postprandial glycemia and lipemia.

The fibres and polyphenols in sea buckthorn (Hippophaë rhamnoides) extraction residues delay postprandial lipemia.

The triacylglycerol (TAG) response to fatty meals containing dried and crushed berries or berry extraction residues was studied in a postprandial cross-over study with healthy normal-weight male volunteers. The berry material included sea buckthorn berries, sea buckthorn CO₂ extraction residue (CO₂-sea buckthorn) and sea buckthorn or black currant CO₂ and ethanol extraction residue (CO₂-EtOH-sea buckthorn, CO₂-EtOH-black currant). Extraction residues were used in order to advance the potential use of valuable side stream components containing polyphenols and fibre as human food.

Flavonol glycosides of sea buckthorn (Hippophaë rhamnoides ssp. sinensis) and lingonberry (Vaccinium vitis-idaea) are bioavailable in humans and monoglucuronidated for excretion.

Glucuronidation and excretion of sea buckthorn and lingonberry flavonols were investigated in a postprandial trial by analyzing the intact forms of flavonol glycosides as well as glucuronides in plasma, urine, and feces. Four study subjects consumed sea buckthorn (study day 1) and lingonberry (study day 2) breakfasts, and blood, urine, and fecal samples were collected for 8, 24, and 48 h, respectively. Both glycosides and glucuronides of the flavonol quercetin as well as kaempferol glucuronides were detected in urine and plasma samples after the consumption of lingonberries; 14% of flavonols in urine were glycosides, and 86% were glucuronidated forms (wt %).

Urinary excretion of the main anthocyanin in lingonberry (Vaccinium vitis-idaea), cyanidin 3-O-galactoside, and its metabolites.

In vitro trials have indicated various potential health effects of lingonberries ( Vaccinium vitis-idaea L.). Most of these studies have been performed with berry extract or juice, and the detailed chemical structures of active compounds in these products have not been elucidated.