The Acquisition of a Diglossic Language by Deaf and Hard of Hearing Students: Evidence From a Sentence Production Task.

Purpose: The current study aimed to examine morphosyntactic errors in sentences produced by DHH students, who are signers of Israeli Sign Language, and also users of Palestinian Colloquial Arabic (PCA) and written Modern Standard Arabic (MSA).

Method: Nineteen school-age DHH students participated in a sentence elicitation task in which they retold events portrayed in 24 videos in PCA and MSA. A control group of 19 hearing students was tested with the same task.

shinyExprPortal: a configurable 'shiny' portal for sharing analysis of molecular expression data.

Motivation: The scale of omics research presents many obstacles to full sharing and access to analysis results. Current publication models impose limits on the number of pages and figures, requiring careful preparation and selection of content. At the same time, depositing data in open repositories significantly shifts the burden of access and reproduction to readers, who may include people who are not programmers or analysts.

Prevalence of multimorbidity in survivors of 28 cancer sites: an English nationwide cross-sectional study.

Multimorbidity, the presence of a chronic condition in addition to cancer, is of particular importance to cancer survivors. It has an impact on the progression, stage at diagnosis, prognosis, and treatment of cancer patients. Evidence is scarce on the prevalence of specific comorbidities in survivors of different cancers to inform prevention and management of multimorbidity.

Ethnic differences in early onset multimorbidity and associations with health service use, long-term prescribing, years of life lost, and mortality: A cross-sectional study using clustering in the UK Clinical Practice Research Datalink.

Background: The population prevalence of multimorbidity (the existence of at least 2 or more long-term conditions [LTCs] in an individual) is increasing among young adults, particularly in minority ethnic groups and individuals living in socioeconomically deprived areas. In this study, we applied a data-driven approach to identify clusters of individuals who had an early onset multimorbidity in an ethnically and socioeconomically diverse population. We identified associations between clusters and a range of health outcomes.

GEOexplorer: a webserver for gene expression analysis and visualisation.

Gene Expression Omnibus (GEO) is a database repository hosting a substantial proportion of publicly available high throughput gene expression data. Gene expression analysis is a powerful tool to gain insight into the mechanisms and processes underlying the biological and phenotypic differences between sample groups. Despite the wide availability of gene expression datasets, their access, analysis, and integration are not trivial and require specific expertise and programming proficiency.

Therapeutic diminution of Interleukin-10 with intranasal theophylline administration in hyposmic patients.

Objective: To determine changes in nasal mucus Interleukin-10 (IL-10) before and after intranasal theophylline treatment in hyposmic patients, and the relationship of these changes to orally administered theophylline treatment.

Design: IL-10 was measured in nasal mucus samples of 17 normal subjects and 39 patients with hyposmia of multiple etiologies by use of a sensitive spectrophotometric ELISA assay. Hyposmia is defined clinically by standardized evaluation of impaired olfactometry, as well as subjectively self reported by the patient.

Words of Estimative Correlation: Studying Verbalizations of Scatterplots.

Natural language and visualization are being increasingly deployed together for supporting data analysis in different ways, from multimodal interaction to enriched data summaries and insights. Yet, researchers still lack systematic knowledge on how viewers verbalize their interpretations of visualizations, and how they interpret verbalizations of visualizations in such contexts. We describe two studies aimed at identifying characteristics of data and charts that are relevant in such tasks.

VASABI: Hierarchical User Profiles for Interactive Visual User Behaviour Analytics.

User behaviour analytics (UBA) systems offer sophisticated models that capture users' behaviour over time with an aim to identify fraudulent activities that do not match their profiles. Motivated by the challenges in the interpretation of UBA models, this paper presents a visual analytics approach to help analysts gain a comprehensive understanding of user behaviour at multiple levels, namely individual and group level. We take a user-centred approach to design a visual analytics framework supporting the analysis of collections of users and the numerous sessions of activities they conduct within digital applications.

Theophylline increases saliva sonic hedgehog and improves taste dysfunction.

Objective: To determine changes in saliva sonic hedgehog (Shh) and in taste dysfunction before and after oral theophylline treatment.

Design: Shh was measured in parotid saliva of both normal subjects and patients with taste dysfunction of multiple etiologies by use of a sensitive spectrophotometric ELISA assay. Taste dysfunction was defined clinically by both subjective inhibition of taste function (including acuity loss) and impaired gustometry.

Sonic hedgehog is present in parotid saliva and is decreased in patients with taste dysfunction.

Purpose: To demonstrate that sonic hedgehog (Shh) is present in human parotid saliva and is decreased in human taste dysfunction.

Methods: Shh was measured in parotid saliva of 27 normal subjects and 81 patients with taste dysfunction of multiple etiologies using a sensitive spectrophotometric ELISA assay. Taste dysfunction was defined clinically both by subjective decreases of taste acuity and flavor perception and by impaired gustometry.

A genetic marker of the ACKR1 gene is present in patients with Type II congenital smell loss who have type I hyposmia and hypogeusia.

Purpose: Our previous study of Type II congenital smell loss patients revealed a statistically significant lower prevalence of an FY (ACKR1, formerly DARC) haplotype compared to controls. The present study correlates this genetic feature with subgroups of patients defined by specific smell and taste functions.

Methods: Smell and taste function measurements were performed by use of olfactometry and gustometry to define degree of abnormality of smell and taste function.

Improved smell function with increased nasal mucus sonic hedgehog in hyposmic patients after treatment with oral theophylline.

Purpose: We previously demonstrated the presence of sonic hedgehog (Shh) in nasal mucus in normal subjects and in patients with smell loss (hyposmia). Nasal mucus Shh levels were found significantly diminished in untreated hyposmic patients of multiple etiologies. Since treatment with oral theophylline has been previously associated with improvement in smell function we wished to study if such treatment increased nasal mucus Shh as well as improved smell function in patients with hyposmia.

On the mechanism of smell loss in patients with Type II congenital hyposmia.

Background: Smell function has been initiated with theophylline treatment in 63% of patients with Type II congenital smell loss. Based upon a systematic evaluation of the protein components of nasal mucus we have demonstrated that interactions among four chemical moieties in nasal mucus may play significant roles in this initiation. Prior to treatment three of these moieties, cAMP, cGMP and sonic hedgehog (Shh), were significantly decreased in concentration whereas one of these moieties, TNFalpha, was increased in concentration.

Initiation of smell function in patients with congenital hyposmia.

Background: Patients with congenital smell loss (hyposmia) are born without a sense of smell. They comprise two types. Type I patients have genetic abnormalities manifested by brain, gonadal and other somatic abnormalities.

Erythrocyte membrane antigen frequencies in patients with Type II congenital smell loss.

Objective: The objective of this study was to determine whether there are genetic factors associated with Type II congenital smell loss.

Study Design: The expression frequencies of 16 erythrocyte antigens among patients with Type II congenital smell loss were determined and compared to those of a large control group.

Methods: Blood samples were obtained from 99 patients with Type II congenital smell loss.

Effects of smell loss (hyposmia) on salt usage.

Objective: Smell loss (hyposmia) inhibits flavor perception and influences food intake. To compensate for flavor loss, some patients with hyposmia appear to increase salt usage. The purpose of this study was to compare self-reported salt usage in patients with hyposmia with that in normal volunteers.

Anatomic olfactory structural abnormalities in congenital smell loss: magnetic resonance imaging evaluation of olfactory bulb, groove, sulcal, and hippocampal morphology.

Background And Purpose: There are 2 groups of patients with congenital smell loss: group 1 (12% of the total), in which patients exhibit a familial smell loss in conjunction with severe anatomical, somatic, neurological, and metabolic abnormalities such as hypogonadotropic hypogonadism; and a larger group, group 2 (88% of the total), in which patients possess a similar degree of smell loss but without somatic, neurological, or anatomical abnormalities or hypogonadism. Both groups are characterized by similar olfactory dysfunction, and both have been reported to have absent or decreased olfactory bulbs and grooves, which indicates some overlap in olfactory pathophysiology and anatomy. The purpose of this study was to evaluate patients with congenital smell loss, primarily among group 2 patients, comparing brain magnetic resonance imaging (MRI) results in patients with types of hyposmia.

Interleukin 6 in hyposmia.

Importance: Olfaction is a complex sensory process that has not been fully studied. Elevated plasma levels of interleukin 6 (IL-6) have been found in patients with several acute and chronic diseases but have not been reported in patients with smell loss (hyposmia).

Objective: To determine IL-6 levels in patients with hyposmia.