Pulsed Radiofrequency of the Auriculotemporal Nerve to Reduce the Intensity of Tinnitus.

Introduction: Stimulation of the nonauditory nervous systems via the trigeminal nerve pathways can be a promising intervention for patients with tinnitus refractory to medical, conservative, and other treatment options. Therapy of the mandibular division of the trigeminal nerve through the auriculotemporal nerve has been reported as useful for patients with tinnitus.

Objectives: The objective of our study was to study the long-term effects of pulsed radiofrequency of the auriculotemporal nerve in a large group of tinnitus sufferers and to find predictors for a prosperous result.

Pulsed Radiofrequency of the Auricular Branch of the Vagal Nerve in Tinnitus Patients.

Introduction: Pulsed radiofrequency of the auricular branch of the vagal nerve has strongly reduced tinnitus in a person with violent tinnitus and severe cervical pain.

Objectives: The objective of our study was to study the long-term effects of pulsed radiofrequency of the auricular branch of the vagal nerve in a large group of tinnitus sufferers and to find predictors for a prosperous result.

Design: A monocenter backward-looking group study.

Tibial Nerve Block as Treatment of Chronic Foot Pain.

Background: Minimally invasive therapies can alleviate pain and improve walking in individuals with persistent foot and ankle pain.

Objectives: The current study aimed to define the protracted consequences of tibial nerve blocks with steroids for individuals with persistent foot pain and to investigate the link between the thermography of the plantar foot and the beneficial effect of a tibial nerve block with steroids.

Methods: All patients with chronic foot pain (n = 45) in this cohort underwent a block of the tibial nerve in the Department of Pain Therapy of Pain Clinic De Bilt, Utrecht, Netherlands, within November 2019 to April 2020.

Pulsed Radiofrequency of the Vagal Nerve for Tinnitus -A Case-Study.

Tinnitus Background: Vagal nerve stimulation is a promising therapy for tinnitus. Pulsed radiofrequency is a minimally invasive neuromodulator technique that could be applied repeatedly without damage to neural tissue. In this case-study we document the use of pulsed radiofrequency of the vagal nerve as a successful therapy without harm for patients with tinnitus.

Pain in relationship to Tinnitus and Hearing Loss.

Introduction: Cervical and lower back pain are noteworthy in the manner of development of tinnitus.

Objectives: The focus of this research was to indicate the consequence of the severity of neck pain and pain of the lower back and/or lower limbs in tinnitus patients.

Design: A retrospective analysis of 61 patients with tinnitus as main complaint during a three month period.

Amplifiers in Tinnitus Patients.

Introduction: High tinnitus loudness can be provoked by peripheral disorders of the somatosensory and/or auditory system.

Objectives: The object of our study was to compare high tinnitus loudness patients with low tinnitus loudness patients and to find specific factors associated with high tinnitus loudness.

Design: A retrospective cohort analysis of 234 patients with tinnitus as main complaint who visited our clinic in a four-year period.

Is Pain Harder To Withstand Than Tinnitus?

Objectives: The object of the study was to compare the perception of tinnitus with the perception of pain and to find specific factors that could influence the perception of both pain and tinnitus.

Design: A retrospective analysis of 124 patients with tinnitus as main complaint and 300 patients with cervical pain as main complaint who visited our clinic in a two-year period.

Results: This study indicates that it is harder to withstand cervical pain than tinnitus with a higher prevalence of fatigue and impaired work performance in cervical pain patients.

Proprioception: the missing link in the pathogenesis of tinnitus?

Objectives: The object of this study was to relate cervical spine pathology to the occurrence of tinnitus and of cervical pain.

Design: A retrospective analysis of 124 patients with tinnitus as main complaint and 300 patients with cervical pain as main complaint who visited our clinic in a two-year period.

Results: In patients with tinnitus as main complaint, 64% of the patients have also cervical pain, and in patients with cervical pain as main complaint, 44% of the patients have tinnitus.

Cervical Nerve Projections to the Auditory Pathway in Tinnitus.

Introduction: Cervical spinal nerves project to the auditory system and take part in the pathology of tinnitus.

Objectives: The intention of our research was to estimate the outcome of treatment of C6 and C7 to lessen tinnitus intensity and to find criteria for a long-term success.

Design: Subjects were 78 tinnitus patients who were treated with infiltration of the sixth and seventh cervical nerve.

Somatosensory-Auditory Processing of the Fifth Cervical Nerve in Tinnitus.

Introduction: Cervical spinal nerve projections influence auditory responses and play a role in the pathology of tinnitus.

Objectives: The intention of our research was to lay down the amenity of treatment of the fifth (C5) cervical nerve to lessen tinnitus and to obtain specifications associated with a long-term effect of this method.

Design: Subjects were 54 tinnitus patients who were treated with infiltration of the fifth cervical nerve.

Upper Cervical Nerves Can Induce Tinnitus.

Introduction: Treating cervical spine disorders can result in a reduction of tinnitus.

Objectives: The object of the study was to ascertain the benefit of therapy of the third and fourth cervical nerves in reducing tinnitus and to assess parameters indicating a long-term relief.

Design: Subjects were 37 tinnitus patients who were treated with infiltration of the third and fourth cervical nerves.

The eight cervical nerve and its role in tinnitus.

Introduction: The eight cervical nerve might be a source of input to the auditory system.

Objectives: The object was to assess the efficacy of infiltration of the eight cervical nerve root for treating tinnitus patients and to find indicators for a successful result.

Design: Retrospective cohort study.

Psychosocial consequences of the loudness of tinnitus.

Introduction: Tinnitus distress is associated with the perceived loudness of the tinnitus.

Objectives: To evaluate the psychosocial problems in tinnitus patients and to explore any relation with the tinnitus loudness.

Design: From all patients who were treated in our clinic from January 2017 to September 2019 for their tinnitus, patients chart and a questionnaire with the psychosocial variables were studied retrospectively.

Pulsed radiofrequency of C2 dorsal root ganglion in patients with tinnitus.

Introduction: The second cervical nerve ganglion bar appears to be beneficial in patients with treatment safe tinnitus. As far as anyone is concerned, the viability of this methodology in patients with tinnitus has never been evaluated.

Objectives: The point of this investigation was to decide the adequacy of beat radiofrequency of C2 dorsal root ganglion for treating patients with tinnitus, and all the more explicitly, to survey the parameters related with a long haul advantage so as to improve understanding determination.

Sleep Disturbances Associated With Tinnitus: Reduce the Maximal Intensity of Tinnitus.

Introduction: The high prevalence together with the serious impact of sleep disturbances assessed in tinnitus patients urge the need for effective therapy that could improve patients' sleep quality.

Objectives: The purpose of this study was to assess the reported prevalence and severity of sleep disturbance in chronic tinnitus patients and to extract possible tinnitus specific factors that increase the risk of developing sleep disturbances.

Design: Subjects were 165 consecutive patients who came to our clinic from January 2017 to January 2019 for consultations on their tinnitus that persisted for one month or longer.

Temporomandibular steroids in patients with tinnitus: Only on indication.

Introduction: Patients with tinnitus without an identifiable cause may have temporomandibular joint dysfunction and can be treated by an intra-articular injection of steroids.

Objectives: The aim of this study was to determine the efficacy of temporomandibular steroids for treating patients with tinnitus, and more specifically, to assess the parameters associated with a long-term benefit in order to improve patient selection.

Design: Subjects were 70 consecutive patients who came to our clinic from October 2016 to October 2018 for consultations on their tinnitus that persisted for one month or longer and were treated with an intra-articular injection of the temporomandibular joint with steroids.

Percutaneous Radiofrequency Lesion of the Superior Cervical Sympathetic Ganglion in Patients with Tinnitus.

Objective: The aim of this study was to determine the efficacy of radiofrequency lesioning of the superior cervical sympathetic ganglion for patients with tinnitus.

Study Design: This is a retrospective long-term clinical review of patients with tinnitus treated with a blockade of the superior cervical sympathetic ganglion.

Setting: The human subjects were 366 consecutive patients who came to the DC Klinieken in Almere and Amsterdam from January 2010 to January 2014 for consultations on their tinnitus that persisted for 1 month or longer.

Protocadherin-1 binds to SMAD3 and suppresses TGF-β1-induced gene transcription.

Genetic studies have identified Protocadherin-1 (PCDH1) and Mothers against decapentaplegic homolog-3 (SMAD3) as susceptibility genes for asthma. PCDH1 is expressed in bronchial epithelial cells and has been found to interact with SMAD3 in yeast two-hybrid (Y2H) overexpression assays. Here, we test whether PCDH1 and SMAD3 interact at endogenous protein levels in bronchial epithelial cells and evaluate the consequences thereof for transforming growth factor-β1 (TGF-β1)-induced gene transcription.

Reduced effect of percutaneous retrogasserian glycerol rhizolysis in trigeminal neuralgia affecting the third branch.

Introduction: The objective of this study was to determine the long-term efficacy of percutaneous glycerol rhizolysis of the trigeminal ganglion for treating patients with trigeminal neuralgia and search for predictors associated with (long-term) benefit to improve patient selection.

Methods: A retrospective study in 60 consecutive patients treated with percutaneous glycerol rhizolysis of the trigeminal ganglion for trigeminal neuralgia. Charts were reviewed in combination with follow-up by questionnaire (n = 55, 92% response).

Mouse protocadherin-1 gene expression is regulated by cigarette smoke exposure in vivo.

Protocadherin-1 (PCDH1) is a novel susceptibility gene for airway hyperresponsiveness, first identified in families exposed to cigarette smoke and is expressed in bronchial epithelial cells. Here, we asked how mouse Pcdh1 expression is regulated in lung structural cells in vivo under physiological conditions, and in both short-term cigarette smoke exposure models characterized by airway inflammation and hyperresponsiveness and chronic cigarette smoke exposure models. Pcdh1 gene-structure was investigated by Rapid Amplification of cDNA Ends.

Relationship between Sensory Stimulation and Side Effects in Percutaneous Radiofrequency Treatment of the Trigeminal Ganglion.

Introduction: The objective of this study was to determine the efficacy of percutaneous radiofrequency (RF) treatment of the trigeminal ganglion for treating patients with trigeminal neuralgia, to determine which patients have a long-term benefit, and to evaluate the effect of RF parameters.

Methods: A retrospective study in 28 consecutive patients in combination with a follow-up questionnaire (n = 26, 93% response).

Results: An initial treatment effect of 89% was observed, 60% sustained at 12-month follow-up.

A different approach to treatment-resistant tinnitus: pulsed radiofrequency to the ganglion C2.

Tinnitus represents one of the most common and distressing otologic problems, and it causes various somatic and psychological disorders that interfere with the quality of life. Treatments for tinnitus include pharmacotherapy, cognitive and behavioral therapy, sound therapy, music therapy, tinnitus retraining therapy, massage and stretching, and electrical suppression. In this case report we present a potential treatment, namely pulsed radiofrequency to the ganglion C2.

Characterization of protocadherin-1 expression in primary bronchial epithelial cells: association with epithelial cell differentiation.

Protocadherin-1 (PCDH1) is a novel susceptibility gene for asthma that is expressed in airway epithelium. We aimed to characterize PCDH1 mRNA transcripts and protein expression in primary bronchial epithelial cells and to determine regulation of PCDH1 during mucociliary differentiation. Total RNA and protein were isolated from human primary bronchial epithelial cells.

Protocadherin-1 polymorphisms are associated with eczema in two Dutch birth cohorts.

Background:   Eczema and asthma share a common genetic background and show linkage to chromosome 5q31-33. Protocadherin-1 (PCDH1) is located in this region and was identified as a susceptibility gene for bronchial hyper-responsiveness (BHR), a hallmark of asthma. PCDH1 encodes an adhesion molecule, expressed in airway and skin epithelium.

Meningitis after invasive treatment of the trigeminal ganglion: two case reports and a review of the literature.

Objectives: The objective of this case is to report the rare complication of a meningitis after an invasive treatment of the trigeminal ganglion.

Methods: In this case report, two cases of meningitis due to oral streptococci are reported and a review of literature is presented.

Results And Discussion: This complication should be recognized as early as possible to prevent deterioration of the situation.