Publications by authors named "Henk H D F Schallig"
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection results in a spectrum of clinical presentations. Evidence from Africa indicates that significantly less COVID-19 patients suffer from serious symptoms than in the industrialized world. We and others previously postulated a partial explanation for this phenomenon, being a different, more activated immune system due to parasite infections.
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- The study assessed the effectiveness of a loop-mediated isothermal amplification (LAMP) assay for diagnosing visceral leishmaniasis (VL) in Ethiopia, showing a high sensitivity of 95.9% and specificity of 98.0%.
- LAMP demonstrated strong performance against existing methods, detecting 94.3% of microscopy-positive cases and 94.2% of rK39-positive cases, with particularly high sensitivity in HIV-positive patients (100%).
- Combining rK39 serology with LAMP could achieve a remarkable sensitivity of 99.2% and retains a specificity of 98.0%, showcasing LAMP as a rapid and reliable diagnostic option for VL, even in HIV co-in