Publications by authors named "Hengzhe Lu"
Colorectal cancer is among the most frequently diagnosed cancers with high mortality rates and poses a serious threat to human health. Genistein (Gen) has been found to have anti-colorectal cancer effects, however, the molecular mechanisms by which genistein elicits its effects on colorectal cancer (CRC) cells have not been fully elucidated. In this study, we investigated the oxidative state of colorectal cancer cells during the antitumor action of Genistein and whether it can exert its antitumor effects through ferroptosis.
View Article and Find Full Text PDFEmerging Therapeutic Approaches Targeting Ferroptosis in Cancer: Focus on Immunotherapy and Nanotechnology.
Curr Pharm Biotechnol
September 2024
Ferroptosis is a newly discovered form of programmed cell death characterized by iron overload, ROS accumulation, and lipid peroxidation. It is distinguished by unique morphological, biochemical, and genetic features and stands apart from other known regulated cell death mechanisms. Studies have demonstrated a close association between ferroptosis and various cancers, including liver cancer, lung cancer, renal cell carcinoma, colorectal cancer, pancreatic cancer, and ovarian cancer.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how magnetic moments in thin CrOCl, a frustrated antiferromagnet, are stabilized through coupling with different degrees of freedom, particularly lattice distortions affecting magnetic orientation.
- It reveals that the transitions between antiferromagnetic and ferrimagnetic states in CrOCl occur through a novel mechanism involving collective flipping of magnetic moments, rather than the previously understood spin-flop process.
- Additionally, the changes in electronic properties during these transitions offer potential for innovative applications in spintronics and exploring unusual physical phenomena in two-dimensional materials.
Room-temperature two-dimensional antiferromagnetic (AFM) materials are highly desirable for various device applications. In this letter, we report the low-energy electronic structure of KMnBi measured by angle-resolved photoemission spectroscopy, which confirms an AFM ground state with the valence band maximum located at -100 meV below the Fermi level and small hole effective masses associated with the sharp band dispersion. Using complementary Raman, atomic force microscope and electric transport measurement, we systematically study the evolution of electric transport characteristics of micro-mechanically exfoliated KMnBi with varied flake thicknesses, which all consistently reveal the existence of a probable AFM ground state down to the quintuple-layer regime.
View Article and Find Full Text PDFArticle Synopsis
- This study explores how spin-orbit coupling (SOC) and the Stark effect interact in few-layer black arsenic, a non-centrosymmetric two-dimensional electronic material, leading to unique quantum phenomena.
- The interplay results in the formation of asymentrical particle-hole states and tunable Rashba valleys, which are influenced by an applied electric field that breaks symmetry in the material's structure.
- The findings reveal unconventional transitions in quantum Hall states and changes in band topology, demonstrating potential applications for controlling electronic properties in two-dimensional systems using electrostatic gating.