Comparative genomic analysis of plasmids harboring -like genes in .

The emergence and spread of carbapenem-resistant (CRKP) is a serious medical problem worldwide. Acquired OXA-48-like carbapenemases encoded by plasmids are important causes of carbapenem resistance in . To explore the links between plasmids and -like genes in , we systematically analyzed the variants of -like plasmid replicon types, phylogenetic patterns, geographic distribution, conjugative transfer regions, and the genetic environments surrounding -like of 191 -like-harboring plasmids, which were identified from 4451 plasmids of downloaded from GenBank.

Characterization of -Harboring Conjugative Plasmids in Acinetobacter Species.

New Delhi metallo-β-lactamase (NDM)-producing clinical strains in Acinetobacter spp. have been recently reported in many countries and have received considerable attention. The vast majority of cases occur on conjugative plasmids, which play a vital role in disseminating .

Genetic Diversity and Characteristics of -Positive Plasmids in .

New Delhi metallo-β-lactamases (NDMs), including at least 28 variants, are a rapidly emerging family of β-lactamases worldwide, with a variety of infections caused by NDM-positive strains usually associated with very poor prognosis and high mortality. NDMs are the most prevalent carbapenemases in () worldwide, especially in China. The vast majority of cases occur on plasmids, which play a vital role in the dissemination of .