In-Sensor Computing with Visual-Tactile Perception Enabled by Mechano-Optical Artificial Synapse.

In-sensor computing paradigm holds the promise of realizing rapid and low-power signal processing. Constructing crossmodal in-sensor computing systems to emulate human sensory and recognition capabilities has been a persistent pursuit for developing humanoid robotics. Here, an artificial mechano-optical synapse is reported to implement in-sensor dynamic computing with visual-tactile perception.

Performance of ddPCR-GNB for microbial diagnosis of suspected bloodstream infection due to the four most common gram-negative bacteria: a prospective, multicenter study.

Unlabelled: We aimed to validate the performance of ddPCR-GNB, a plasma droplet digital PCR panel targeting the four most common gram-negative bacteria, for patients with suspected bloodstream infection (BSI). Patients suspected of having BSIs were prospectively enrolled. The results of blood culture and ddPCR-GNB were compared, and cases with discordant results were arbitrated on the basis of additional microbiological results and clinical evidence.

Engineering of CD8 T cells with an HIV-specific synthetic notch receptor to secrete broadly therapeutic antibodies for combining antiviral humoral and cellular immune responses.

The application of immunotherapeutic strategies, such as chimeric antigen receptor-T cells and broadly neutralizing antibodies (bNAbs), for the treatment of human immunodeficiency virus (HIV) infection is hindered by the latent reservoirs and viral escape. Achieving long-term control of viral load in the absence of antiretroviral therapy requires a combination approach utilizing these immunotherapeutic strategies. For this purpose, we developed novel anti-HIV-1 synthetic Notch (synNotch) receptor-T cells, termed CD4-17b-VN, which express both a bNAb (VRC01) and a bispecific T cell-engaging protein (N6-αCD3) with antigenic control.

Predictive Value of a Novel Frailty Index for Cardiovascular Outcomes After Major Noncardiac Surgery: A Prospective Cohort Study.

Background: Older patients undergoing noncardiac surgery are at risk of postoperative cardiovascular events. Accurate cardiovascular risk assessment is important for informed decision-making.

Methods: This prospective cohort study enrolled older patients undergoing elective major noncardiac surgery.

Viral protease binds to nucleosomal DNA and cleaves nuclear cGAS that attenuates type I interferon.

Unlabelled: Nuclear cyclic GMP-AMP synthetase (cGAS) binds to nucleosome with high affinity to prevent its activation by self-DNA. Upon stimulation with double-stranded DNA, cGAS is activated and translocates from the nucleus to the cytoplasm, guided by its N-terminal domain. However, it remains unclear whether viruses can hijack cGAS translocation and regulate its activation.

A effector regulates plant cell death by disrupting the homeostasis of the BPA1-ACD11 complex.

Effectors secreted by phytopathogenic bacteria can suppress ETI responses induced by avirulence effectors, thereby overcoming crop resistance. However, the detailed mechanisms remain largely unknown. We report that the effector RipD from regulates plant cell death in a protein abundance-dependent manner.

Endogenous nitric oxide promotes virulence by activating autophagy.

Endogenous nitric oxide (NO) is a small molecule that has been demonstrated to affect the physiology and survival of bacteria. The role of endogenous NO for survival inside host cells remains unclear. Here, we show that the production of endogenous NO by bacterial nitrate reductase (NR) is affected by molybdopterin biosynthesis protein A (MoeA), which is essential for molybdenum cofactor synthesis in .

Research on PVDF/BNNSs/MXene multilayer films with high energy density and thermal conductivity for dielectric capacitors.

Polyvinylidene fluoride (PVDF) has promising applications in the field of dielectric capacitors. However, its low dielectric constant and thermal conductivity limit energy storage density. To address this, three multilayer composite topologies were designed with PVDF/boron nitride nanosheets as insulation and PVDF/MXene as polarization layers.

Efficacy of Triptorelin Combined with Recombinant Human Growth Hormone (rhGH) on Serum Sex Hormones, Bone Age, and Clinical Outcomes in Girls with Precocious Puberty.

Triptorelin effectively delays bone age progression in children with precocious puberty but may suppress pituitary growth hormone response, affecting growth hormone-binding protein secretion and overall growth rate. This study aimed to evaluate the efficacy and safety of triptorelin alone versus in combination with recombinant human growth hormone (rhGH) in treating girls with precocious puberty. This retrospective study examined 82 girls with precocious puberty treated at The First People's Hospital of Tongxiang from January 2021 to June 2023.

Predictive Value of Serum N-Terminal Pro-Brain Natriuretic Peptide, D-Dimer, Albumin Combined with T-Cell Subsets in Detecting Coronary Artery Damage in Children with Kawasaki Disease.

Kawasaki disease (KD) is the common acute, self-limiting vasculitis in children, often affecting coronary arteries, which may lead to coronary artery dilation, stenosis, or in severe cases, myocardial infarction. This study aimed to identify new approaches for reducing or preventing coronary artery lesions (CAL) in KD patients by analyzing specific serological markers across various paediatric groups. Clinical data were collected from 100 children diagnosed with Kawasaki disease (KD) admitted at First Affiliated Hospital of Hebei North University between May 2023 and June 2024.

RNF20 dual regulation of MDA5 signaling to maintain immune homeostasis in chickens.

Unlabelled: RIG-I and MDA5, known as the RIG-I-like receptors (RLRs), play a pivotal role in inducing antiviral responses to RNA viral infections. While chickens lack RIG-I, they possess a functionally enhanced MDA5 that recognizes pathogens and regulates immunity, underscoring the critical role of MDA5 in maintaining immune homeostasis in chickens. However, the precise mechanisms governing the expression and optimal activation of MDA5 remain unclear.

ConoGPT: Fine-Tuning a Protein Language Model by Incorporating Disulfide Bond Information for Conotoxin Sequence Generation.

Conotoxins are a class of peptide toxins secreted by marine mollusks of the Conus genus, characterized by their unique mechanism of action and significant biological activity, making them highly valuable for drug development. However, traditional methods of acquiring conotoxins, such as in vivo extraction or chemical synthesis, face challenges of high costs, long cycles, and limited exploration of sequence diversity. To address these issues, we propose the ConoGPT model, a conotoxin sequence generation model that fine-tunes the ProtGPT2 model by incorporating disulfide bond information.

Monitoring of Pathogens Carried by Imported Flies and Cockroaches at Shenzhen Ports.

This study tested the efficacy of xenomonitoring using contaminated flies and cockroaches at ports in Shenzhen by analysing sample data from imported flies and cockroaches from October 2023 to April 2024 to identify the pathogens they carried. Among all the samples of flies and cockroaches collected, and accounted for the highest proportion, 27.59% and 66.

Characterization and Source Apportionment Analysis of PM and Ozone Pollution over Fenwei Plain, China: Insights from PM Component and VOC Observations.

PM and volatile organic compounds (VOCs) have been identified as the primary air pollutants affecting the Fenwei Plain (FWP), necessitating urgent measures to improve its air quality. To gain a deeper understanding of the formation mechanisms of these pollutants, this study employed various methods such as HYSPLIT, PCT, and PMF for analysis. Our results indicate that the FWP is primarily impacted by PM from the southern Shaanxi air mass and the northwestern air mass during winter.

Comprehensive Cross-Sectional Study of the Triglyceride Glucose Index, Organophosphate Pesticide Exposure, and Cardiovascular Diseases: A Machine Learning Integrated Approach.

Using NHANES data from 2003 to 2008, 2011 to 2012, and 2015 to 2020, we examined the relationship between urinary organophosphate pesticide (OPP) metabolites and the triglyceride glucose (TyG) index. The TyG index evaluates insulin resistance, a crucial factor in metabolic diseases. Linear regression analyzed urinary metabolites in relation to the TyG index and OPPs.

Ozone Exposure and Gestational Diabetes in Twin Pregnancies: Exploring Critical Windows and Synergistic Risks.

The relationship between ozone (O) exposure and gestational diabetes mellitus (GDM) in twin pregnancies remains unexplored. This study aimed to investigate the association between O exposure and GDM risk in twin pregnancies, and to explore the synergistic effects of O exposure with other maternal factors. A total of 428 pregnancies recruited from a prospective twin cohort were included.

Per- and Poly-Fluoroalkyl Substances, and Organophosphate Flame Retardants in the Upper Yangtze River: Occurrence, Spatiotemporal Distribution, and Risk Assessment.

Contaminants of Emerging Concern (CECs), including per- and polyfluoroalkyl substances (PFASs) and organophosphate flame retardants (OPFRs), have raised global concerns due to their persistence, bioaccumulation potential, and toxicity. This study presents a comprehensive investigation of the occurrence, spatiotemporal distribution, potential sources, and the ecological and human health risks associated with 18 PFASs and 9 OPFRs in the surface waters of the upper Yangtze River, China. The water samples were collected from the main stream and five major tributaries (Min, Jinsha, Tuo, Jialing, and Wu Rivers) in 2022 and 2023.

Toxicological Assessment of Ketamine in Juvenile Zebrafish ().

This study investigates the toxic effects of ketamine on juvenile zebrafish, driven by increasing concerns over ketamine's prevalence and its potential neurotoxic effects that may disrupt behavior and metabolism. Employing a high-throughput behavior tracking system, the research analyzed the locomotor activity of 6-day post-fertilization (6 dpf) zebrafish exposed to various concentrations of ketamine. The integration of behavioral analysis with metabolic profiling was a notable innovation, as it establishes a comprehensive understanding of ketamine's effects on both acute behavioral inhibition and metabolic responses.

A Comprehensive Review of the Application and Potential of Straw Biochar in the Remediation of Heavy Metal-Contaminated Soil.

With the rapid development of industry and agriculture, soil heavy metal contamination has become an important environmental issue faced today and has gradually attracted widespread attention. Finding a cheap, widely available, and biodegradable material that can promote crop growth and stabilize heavy metals has become a research focus. Crop straw biochar, due to its high specific surface area, rich surface functional groups, and high cation exchange capacity (CEC), has shown good effects on the remediation of inorganic and organic pollutants in the environment.

Triphenylphosphine-Initiated Ring-Opening Polymerization for α-Helical Polypeptides and Application in Constructing Artificial Ion Channels.

In this study, we have screened out an effective triphenylphosphine-derived initiator () for efficient ring-opening polymerization of α-amino acid -carboxyanhydrides (NCA ROP) and demonstrated the potential of the prepared helical polypeptide as an efficient ion channel. By optimizing polymerization conditions, exhibited precise control over the molecular weight and polydispersity index for the prepared polypeptides, the universality for different NCA monomers, and the ability to form α-helical secondary structures. By further incorporating ion binding groups and regulating the molecular length, α-helical polypeptide was capable of inserting into lipid bilayers and possessing the function of ion transport (H/K antiport) via a channel mechanism (EC = 12.

Enhancing Oxygen Evolution Catalysis by Tuning the Electronic Structure of NiFe-Layered Double Hydroxides Through Selenization.

Electrocatalytic water splitting is a critical approach for achieving carbon neutrality, playing an essential role in clean energy conversion. However, the slow kinetics of the oxygen evolution reaction (OER) remains a major bottleneck hindering energy conversion efficiency. Although noble metal catalysts (e.

Optimal Methylammounium Chloride Additive for High-Performance Perovskite Solar Cells.

Organic-inorganic lead halide perovskite solar cells (PSCs) have presented promising improvements within recent years due to the superior photophysical properties of perovskites. The efficiency of PSCs is closely related to the quality of the of the perovskite film. Additive engineering is an effective strategy to regulate the crystallization of perovskite film.

Research Progress on High-Temperature-Resistant Electromagnetic Wave Absorbers Based on Ceramic Materials: A Review.

Ceramic materials have the merits of an adjustable dielectric constant, high strength, high temperature resistance, and oxidation resistance, and are thus being used as the protection matrix for carbon series, metal oxides, and other wave-absorbing materials at high temperatures. Here, progress on high-temperature-resistant wave-absorbing ceramic materials is introduced through the aspects of their composition and structure. In addition, metamaterials used for such purposes, which are mainly produced through 3D printing, are also highlighted.

Si-HgTe Quantum Dot Visible-Infrared Photodetector.

Silicon photodetectors are well developed, with the advantage of their low cost and easy fabrication. However, due to the semiconductor band gap limitation, their detection wavelength is limited in the visible and near-infrared ranges. To broaden the detection wavelength, we stacked a mercury telluride (HgTe) colloidal quantum dot (CQD) photodiode and a silicon PIN photodiode in series.

Advanced Low-Dimensional Carbon Nanomaterials for Oxygen Electrocatalysis.

Amid rising global energy demand and worsening environmental pollution, there is an urgent need for efficient energy storage and conversion technologies. Oxygen electrocatalytic reactions, specifically the oxygen reduction reaction (ORR) and the oxygen evolution reaction (OER) are critical processes in these technologies. Low-dimensional carbon nanomaterials, including zero-dimensional carbon dots, one-dimensional carbon nanotubes, and two-dimensional graphene, demonstrate substantial potential in electrocatalysis due to their unique physical and chemical properties.