Publications by authors named "Hengyue Shan"
Article Synopsis
- * The study identifies reversible S-palmitoylation of GSDMD as a regulatory mechanism that influences its cleavage and activity during pyroptosis.
- * Disrupting the palmitoylation process affects pyroptosis and can improve survival in mice suffering from severe septic shock while making them more vulnerable to infections.
Deubiquitinating enzymes (DUBs) are key regulatory components of the ubiquitination system. Many DUBs have been revealed to play key roles in normal physiology and diseases. However, only very limited DUB members have well-characterized inhibitors.
View Article and Find Full Text PDFThe COVID-19 pandemic has been disastrous to society and effective drugs are urgently needed. The papain-like protease domain (PLpro) of SARS-CoV-2 (SCoV2) is indispensable for viral replication and represents a putative target for pharmacological intervention. In this work, we describe the development of a potent and selective SCoV2 PLpro inhibitor, 19.
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