Publications by authors named "Hengxing Su"
Article Synopsis
- Researchers developed a microfluidic chip that effectively purifies CD8 T cells using an optimized CD8 aptamer (A3t-MU), achieving a purity of 98.1%, which is significantly better than traditional methods.
- This chip allows for the efficient isolation of CD8 T cells from various blood sources, facilitating the production of CAR T cells targeting CD4 expressed cells for leukemia treatment.
- The resulting CD4-CAR transduced CD8 T cells demonstrated strong anti-cancer activity and tumor growth inhibition across several leukemia cell lines, highlighting the chip's potential in enhancing adoptive cell therapy.
