Publications by authors named "Hengrong Qian"
Autoimmune diseases are typically characterized by aberrant activation of immune system that leads to excessive inflammatory reactions and tissue damage. Nevertheless, precise targeted and efficient therapies are limited. Thus, studies into novel therapeutic targets for the management of autoimmune diseases are urgently needed.
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- Researchers are investigating the role of TREM-1 in myeloid dendritic cells (mDCs) and its therapeutic potential in systemic lupus erythematosus (SLE), a complex autoimmune disease influenced by epigenetic mechanisms and non-coding RNAs.
- * The study utilized bioinformatics to analyze gene expression differences between SLE patients and healthy individuals, identifying TREM-1 as a key gene related to disease progression and a potential biomarker in serum.
- * Findings showed that activating TREM-1 led to increased mDC activation and inflammation, while targeting it with the miRNA miR-150-5p could potentially mitigate SLE symptoms in lupus mice models.*
Co-inhibitory receptors (IRs) are molecules that protect host against autoimmune reactions and maintain peripheral self-tolerance, playing an essential role in maintaining immune homeostasis. In view of the substantial clinical progresses of negative immune checkpoint blockade in cancer treatment, the role of IRs in autoimmune diseases is also obvious. Several advances highlighted the substantial impacts of T cell immunoglobulin and ITIM domain (TIGIT), a novel IR, in autoimmunity.
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