Chitosan coated fluorescent mesoporous silica for the sensitive and selective detection of HO.

A novel turn-on fluorescent sensor for hydrogen peroxide (HO) was prepared from chitosan (CS) coating mesoporous silica nanoparticles (MSNs) loaded with 1-(4-Aminophenyl)-1,2,2-triphenylethene (TPE-NH) and silver nanoparticles (AgNCs). The surface of MSNs was coated by CS as the gatekeeper and the template for loading of AgNCs. Because of the surface plasmon-enhanced energy transfer (SPEET), AgNCs effectively quenched the fluorescence emission of nanoparticles.

Temperature and HO-operated nano-valves on mesoporous silica nanoparticles for controlled drug release and kinetics.

Temperature and HO dual-responsive nanoparticles were fabricated from ferrocene modified mesoporous silica (MSN-Fc) and β-cyclodextrin-poly(N-isopropylacrylamide) (β-CD-PNIPAM) star-shaped polymer due to the host-guest interactions for controlled drug release. The formation and structure of β-CD-PNIPAM@MSN-Fc composite nanoparticles was confirmed by FTIR, TGA, TEM and N adsorption-desorption isotherms. The size of nanoparticles was about 100-150 nm with well-ordered mesoporous structure and PNIPAM chains coating on the surface as outer shell.

Multi-Responsive Nanocarriers Based on β-CD-PNIPAM Star Polymer Coated MSN-SS-Fc Composite Particles.

A temperature, glutathione (GSH), and HO multi-responsive composite nanocarrier (MSN-SS-Fc@β-CD-PNIPAM) based on β-cyclodextrin-poly(-isopropylacrylamide) (β-CD-PNIPAM) star polymer capped ferrocene modified mesoporous silica nanoparticles (MSN-SS-Fc) was successfully prepared. The surface of the mesoporous silica was first modified by ferrocene (Fc) via a disulfide bond (-SS-) to form an oxidizing and reducing site and then complexed with a β-CD-PNIPAM star shaped polymer through host-guest interactions as a nano-valve to provide temperature responsive characteristics. The structure and properties of the complex nanoparticles were studied by FTIR, TGA, EDS, Zeta potential, and elemental analysis.