Publications by authors named "Hengmin Xu"

Gastric cancer remains a significant global health challenge, causing a substantial number of cancer-related deaths, particularly in China. While the exact causes of gastric cancer are still being investigated, () infection has been identified as the primary risk factor, which triggers chronic inflammation and a multistage progression of gastric lesions that may lead to carcinogenesis over a long latency time. Since the 1990s, numerous efforts have focused on assessing the effectiveness of eradication in preventing new cases of gastric cancer among both the general population and patients who have undergone early-stage cancer treatment.

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Gastric cancer is a leading cause of cancer-related deaths in China. Affecting more than 40% of the world's population, Helicobacter pylori is a major risk factor for gastric cancer. While previous clinical trials indicated that eradication of H.

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Article Synopsis
  • The study explores how Helicobacter pylori treatment and nutritional supplementation might help prevent gastric cancer (GC) and investigates whether these benefits apply differently to individuals based on their genetic risks.
  • It utilizes data from two major cohort studies in China, examining genetic variants linked to the progression of gastric lesions and overall GC risk, with a focus on polygenic risk scores to classify participants.
  • Results indicate significant associations between genetic variants and GC risk, revealing that those with higher polygenic risk scores (PRS) are more susceptible to GC, highlighting the potential impact of targeted treatment and nutritional strategies in high-risk groups.
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Background: Drug users are regarded as a high-risk population for HIV infection. Non-occupational post-exposure prophylaxis (nPEP) is internationally regarded as an effective biomedical prevention against HIV but still a small-scale pilot project in China at present. The aim of this study was to understand drug users' awareness of and willingness to use nPEP service in China.

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