Kinetics Compensation Mechanism in Cosolvent Electrolyte Strategy for Aqueous Zinc Batteries.

Aqueous zinc batteries are the ideal choices to realize intrinsically safe energy storage, but parasitic side reactions make it difficult to achieve in practice. Although the cosolvent electrolyte effectively inhibits zinc dendrites and mitigates unexpected side reactions, it brings inevitable kinetics losses. Here, we systematically investigate and compare the interactions between Zn and various oxygen-coordinated cosolvents under pure aqueous environments and the interactions between Zn and OTf under mixed solvent environments containing different oxygen-coordinated cosolvents.

Temperature-Inert Weakly Solvating Electrolytes for Low-Temperature Lithium-Ion Batteries with Micro-Sized Silicon Anodes.

Cost-effective micro-sized silicon (μSi) anodes with high specific capacity are promising for high-energy-density lithium-ion batteries but face significant volume changes during cycling. Constructing anion-derived, inorganic-rich solid-electrolyte interphase by electrolyte engineering is considered a viable strategy for stabilizing μSi anodes. However, at low temperatures, temperature-dependent anion-dominated solvation and sluggish Li desolvation hinder cyclability and capacity retention.

Ion bridging enables high-voltage polyether electrolytes for quasi-solid-state batteries.

Polyether electrolytes have been widely recognized for their favorable compatibility with lithium-metal, yet they are hampered by intrinsically low oxidation thresholds, limiting their potential for realizing high-energy Li-metal batteries. Here, we report a general approach involving the bridge joints between non-lithium metal ions and ethereal oxygen, which significantly enhances the oxidation stability of various polyether electrolyte systems. To demonstrate the feasibility of the ion-bridging strategy, a Zn ion-bridged polyether electrolyte (Zn-IBPE) with an extending electrochemical stability window of over 5 V is prepared, which enables good cyclability in 4.

Dual-Anion-Rich Polymer Electrolytes for High-Voltage Solid-State Lithium Metal Batteries.

Solid polymer electrolytes (SPEs) are promising candidates for lithium metal batteries (LMBs) owing to their safety features and compatibility with lithium metal anodes. However, the inferior ionic conductivity and electrochemical stability of SPEs hinder their application in high-voltage solid-state LMBs (HVSSLMBs). Here, a strategy is proposed to develop a dual-anion-rich solvation structure by implementing ferroelectric barium titanate (BTO) nanoparticles (NPs) and dual lithium salts into poly(vinylidene fluoride) (PVDF)-based SPEs for HVSSLMBs.

Enhancing Stability and 6C Fast Charging in µSi||LiNiCoMnO Lithium-Ion Batteries Using Conductive Binders With Multiple Hydrogen Bonds.

Micro-sized silicon (µSi) anodes are an attractive alternative to graphite for high-energy lithium-ion batteries (LIBs) due to their low cost and high specific capacity. However, they suffer from severe volume expansion during lithiation, leading to fast capacity decay and poor rate capability. Herein, a new hybrid binder featuring a cross-linked conductive network and multiple hydrogen bonds for µSi anodes with high areal capacity is reported.

Paeoniflorin Attenuates Oxidative Stress and Inflammation in Parkinson's Disease by Activating the HSF1-NRF1 Axis.

This study is to explore the effects of paeoniflorin (PF) on oxidative stress (OS) and inflammation in Parkinson's disease (PD) via the HSF1-NRF1 axis. SH-SY5Y cells were pretreated with PF and induced with α-synuclein preformed fibrils (PFF), followed by gain- and loss-of-function assays. Afterward, detection was conducted on cell viability, mitochondrial membrane potential ([Formula: see text]m), and reactive oxygen species (ROS), cyclooxygenase (COX)-2, and inducible nitric oxide synthase (iNOS) levels.

Strengthened High-Concentration Quasi-Solid Electrolytes for Lithium Metal with Ultralong Stable Cyclability.

The lithium metal batteries coupled with nickel-rich LiNiCoMnO ( > 0.7) cathodes hold promise for surpassing the current energy density limit of lithium-ion batteries. However, conventional electrolytes containing free active solvents are highly susceptible to decomposition, particularly at the interfaces of lithium anode and high-voltage cathode.

Diosgenin alleviates arsenic trioxide induced cardiac fibrosis by inhibiting endothelial mesenchymal transition.

Backgroud: Arsenic trioxide (ATO), the first-line drug in treating acute premyelogenous leukemia, has the profound side effect of inducing endothelial mesenchymal transition (EndMT) and causing cardiac fibrosis. Diosgenin (DIO), a pharmaceutical compound found in Paris polyphylla, exhibits promising potential in safeguarding cardiovascular health by mitigating EndMT.

Purpose: This study aims to explore the role and mechanism of DIO in ATO-induced myocardial fibrosis to provide a novel therapeutic agent for ATO-induced cardiac fibrosis.

THBru attenuates diabetic cardiomyopathy by inhibiting RAGE-dependent inflammation.

Diabetic cardiomyopathy (DCM) is a complication of diabetes mellitus characterized by heart failure and cardiac remodeling. Previous studies show that tetrahydroberberrubine (THBru) retrogrades cardiac aging by promoting PHB2-mediated mitochondrial autophagy and prevents peritoneal adhesion by suppressing inflammation. In this study we investigated whether THBru exerted protective effect against DCM in db/db mice and potential mechanisms.

The Therapeutic Potential of Four Main Compounds of (Roxb.) DC: A Comprehensive Study on Biological Processes, Anti-Inflammatory Effects, and Myocardial Toxicity.

(Roxb.) DC. () is a traditional Chinese medicinal plant that is indigenous to the southern regions of China.

Promoting high-voltage stability through local lattice distortion of halide solid electrolytes.

Stable solid electrolytes are essential to high-safety and high-energy-density lithium batteries, especially for applications with high-voltage cathodes. In such conditions, solid electrolytes may experience severe oxidation, decomposition, and deactivation during charging at high voltages, leading to inadequate cycling performance and even cell failure. Here, we address the high-voltage limitation of halide solid electrolytes by introducing local lattice distortion to confine the distribution of Cl, which effectively curbs kinetics of their oxidation.

Interfacial self-healing polymer electrolytes for long-cycle solid-state lithium-sulfur batteries.

Coupling high-capacity cathode and Li-anode with solid-state electrolyte has been demonstrated as an effective strategy for increasing the energy densities and safety of rechargeable batteries. However, the limited ion conductivity, the large interfacial resistance, and unconstrained Li-dendrite growth hinder the application of solid-state Li-metal batteries. Here, a poly(ether-urethane)-based solid-state polymer electrolyte with self-healing capability is designed to reduce the interfacial resistance and provides a high-performance solid-state Li-metal battery.

MiR-203 improves cardiac dysfunction by targeting PARP1-NAD axis in aging murine.

Heart aging is a prevalent cause of cardiovascular diseases among the elderly. NAD depletion is a hallmark feature of aging heart, however, the molecular mechanisms that affect NAD depletion remain unclear. In this study, we identified microRNA-203 (miR-203) as a senescence-associated microRNA that regulates NAD homeostasis.

Combining Solid Solution Strengthening and Second Phase Strengthening for Thinning Li Metal Foils.

Thin lithium (Li) metal foils have been proved to be indispensable yet elusive for practical high-energy-density lithium batteries. Currently, the realization of such thin foils (<50 μm) is impeded by the inferior mechanical processability of metallic Li. In this work, we demonstrate that the combination of solid solution strengthening and second phase strengthening, achieved by the addition of silver fluoride (AgF) to Li metal, can substantially enhance both the strength and ductility of metallic Li.

Tetrahydroberberrubine prevents peritoneal adhesion by suppressing inflammation and extracellular matrix accumulation.

Peritoneal adhesion is a common abdominal surgical complication that induces abdominal haemorrhage, intestinal obstruction, infertility, and so forth. The high morbidity and recurrence rate of this disease indicate the need for novel therapeutic approaches. Here, we revealed the protective roles of tetrahydroberberrubine (THBru), a novel derivative of berberine (BBR), in preventing peritoneal adhesion and identified its underlying mechanism in vivo and in vitro.

Negatively Charged Laponite Sheets Enhanced Solid Polymer Electrolytes for Long-Cycling Lithium-Metal Batteries.

Solid polymer electrolytes suffer from the low ionic conductivity and poor capability of suppressing lithium dendrites, which have greatly hindered the practical application of solid-state lithium-metal batteries. Here, we report a novel laponite sheet (LS) with a large negatively charged surface as an additive in a solid composite electrolyte (poly(ethylene oxide)-LS) to rearrange the lithium-ion environment and enhance the mechanical strength of the electrolytes (PEO-LS). The strong electrostatic regulation of laponite sheets assists the dissociation of lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) and constructs multiple transport channels for free lithium ions, achieving a high ionic conductivity of 1.

Nitidine chloride induces cardiac hypertrophy in mice by targeting autophagy-related 4B cysteine peptidase.

Nitidine chloride (NC) is a standard active component from the traditional Chinese medicine Zanthoxylum nitidum (Roxb.) DC. (ZN).

Tetrahydroberberrubine retards heart aging in mice by promoting PHB2-mediated mitophagy.

Heart aging is characterized by left ventricular hypertrophy and diastolic dysfunction, which in turn induces a variety of cardiovascular diseases. There is still no therapeutic drug to ameliorate cardiac abnormities in heart aging. In this study we investigated the protective effects of berberine (BBR) and its derivative tetrahydroberberrubine (THBru) against heart aging process.

Mitochondrial Homeostasis-Related lncRNAs are Potential Biomarkers for Predicting Prognosis and Immune Response in Lung Adenocarcinoma.

The prognosis of the most common histological subtype of lung cancer, lung adenocarcinoma (LUAD), is relatively poor. Mitochondrial homeostasis depends to a great extent on the coordination between mitophagy and mitochondrial biogenesis, the deregulation of which causes various human diseases, including cancer. There is accumulating evidence that long noncoding RNAs (lncRNAs) are critical in predicting the prognosis and immune response in carcinoma.

LncRNA LOC105378097 inhibits cardiac mitophagy in natural ageing mice.

Background: The development of heart ageing is the main cause of chronic disability, disease and death in the elderly. Ample evidence has established a pivotal role for significantly reduced mitophagy in the ageing heart. However, the underlying mechanisms of mitophagy deficiency in ageing heart are little known.

Building Practical High-Voltage Cathode Materials for Lithium-Ion Batteries.

It has long been a global imperative to develop high-energy-density lithium-ion batteries (LIBs) to meet the ever-growing electric vehicle market. One of the most effective strategies for boosting the energy density of LIBs is to increase the output voltage, which largely depends upon the cathode materials. As the most-promising cathodes for high-voltage LIBs (>4 V vs Li/Li ), four major categories of cathodes including lithium-rich layered oxides, nickel-rich layered oxides, spinel oxides, and high-voltage polyanionic compounds still encounter severe challenges to realize the improvement of output voltage while maintaining high capacity, fast rate capability, and long service life.