Publications by authors named "Hengguan Cui"
Although there have been significant advances in cancer treatment, the urgent need to inhibit breast cancer metastasis remained unmet. Bruceine A (BA) is a natural compound extracted from Bruceae Fructus and has long been recognized to have antitumor effects with high safety and biocompatibility. However, the mechanisms and/or targets of BA for metastatic breast cancer treatment are still not fully elucidated.
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- Recent research indicates that the expression of Sphingosine 1-phosphate receptor 2 (S1PR2) is linked to poor outcomes in patients with non-alcoholic fatty liver disease-related hepatocellular carcinoma (NAFLD-HCC) and impacts tumor behavior.
- Molecular assays showed that S1PR2 influences crucial cell functions like proliferation and migration in HCC cell lines, while in vivo experiments confirmed its role in tumor growth.
- Additionally, Glycodeoxycholic acid (GCDA) interactions with S1PR2 and the PI3K/AKT/mTOR pathway were studied, revealing that JTE-013, an S1PR2 antagonist, could inhibit tumor cell
Background: Hepatic ischemia/reperfusion injury (HIRI) is an unavoidable complication in liver surgery, however its pathological process is still unclear. Therefore, in this study, the role and mechanism of peroxisome proliferator-activated receptor gamma (PPARγ) was investigated in HIRI.
Materials And Methods: We constructed mice models with HIRI and L02 cell models insulted hypoxia/re-oxygenation (H/R).
Background: Gastric cancer is one of the most prevalent and deadly malignancies without efficient treatment option. This study aimed to investigate the effect of hydrogen gas on the behavior of gastric cancer cells.
Methods: Gastric cancer cell lines MGC-803 and BGC-823 were treated with or without H /O gas mixture (66.
Glutathione S-transferase T1 (GSTT1) catalyzes reactions between glutathione and lipophilic compounds with electrophilic centers, leading to neutralization of toxic compounds, xenobiotics, and products of oxidative stress. In the past decade, a number of case-control studies have been carried out to investigate the relationship between the GSTT1 null polymorphism and gastric cancer (GC), but the results have been inconclusive. To investigate this inconsistency, we performed a meta-analysis of 46 studies involving a total of 9012 GC cases and 14,215 controls for null variant of the GSTT1 gene to evaluate the effect of GSTT1 on genetic susceptibility for GC.
View Article and Find Full Text PDFAim: To investigate the clinicopathological roles of Bmi1 in esophageal squamous cell carcinoma (ESCC).
Methods: Quantitative real-time polymerase chain reaction and immunohistochemical staining for Bmi1 were performed in cancerous and adjacent non-cancerous paraffin-embedded esophageal specimens.
Results: The Bmi1 expression level was unaffected by gender and age.