Uncontrolled asthma across GINA treatment steps 2 - 5 in a large US patient cohort.

Objective: Despite advances in treatment, asthma remains uncontrolled in many patients, with increased risk of exacerbation and associated healthcare resource utilization (HCRU). We describe patient characteristics, exacerbations, asthma control, and HCRU using GINA treatment step (GS) as a proxy for asthma severity. .

Evaluation of exacerbations and blood eosinophils in UK and US COPD populations.

Background: Blood eosinophil counts and history of exacerbations have been proposed as predictors of patients with chronic obstructive pulmonary disease (COPD) who may benefit from triple therapy (inhaled corticosteroid, long-acting β-agonist and long-acting muscarinic antagonist).

Methods: In a retrospective cohort analysis we examined the profiles of COPD patients from the UK Clinical Practice Research Datalink (CPRD) and US Optum Clinformatics™ Data Mart (Optum) databases with reference to exacerbation frequency and blood eosinophil distribution.

Results: Of the 31,437 (CPRD) and 383,825 (Optum) patients with COPD, 15,364 (CPRD) and 139,465 (Optum) met the eligibility criteria and were included.

Adherence to tobramycin inhaled powder vs inhaled solution in patients with cystic fibrosis: analysis of US insurance claims data.

Purpose: Tobramycin inhalation powder (TIP), the first dry-powder inhaled antibiotic for pulmonary infection, is associated with reduced treatment burden, increased patient satisfaction, and higher self-reported adherence for cystic fibrosis (CF) patients. We compared adherence in CF patients newly treated with TIP with those newly treated with the traditional tobramycin inhalation solution (TIS), using US insurance claims data.

Patients And Methods: From the Truven MarketScan database, we identified CF patients chronically infected with who had been prescribed TIP between May 1, 2013 to December 31, 2014, or TIS between September 1, 2010 to April 30, 2012 with at least 12 months of continuous medical and pharmacy benefits prior to and following prescription.

Microwave spectra of the deuterium isotopologues of cis-hexatriene and a semiexperimental equilibrium structure.

Microwave transitions and ground state rotational constants are reported for five newly synthesized deuterium isotopologues of cis-1,3,5-hexatriene (cHTE). These rotational constants along with those of the parent and the three (13)C species are used with vibration-rotation constants calculated from an MP2/cc-pVTZ model to derive an equilibrium structure. That structure is improved by the mixed estimation method.

Analysis of the rotational structure in the high-resolution infrared spectrum of trans-hexatriene-1-13C1: a semiexperimental equilibrium structure for the C6 backbone of trans-hexatriene.

trans-Hexatriene-1-(13)C(1) (tHTE-1-(13)C(1)) has been synthesized, and its high-resolution (0.0015 cm(-1)) infrared spectrum has been recorded. The rotational structure in the C-type bands for ν(26) at 1011 cm(-1) and ν(30) at 894 cm(-1) has been analyzed.