Publications by authors named "Hengbin Yang"
Precise genomic editing through the combination of CRISPR/Cas systems and recombinant adeno-associated virus (rAAV)-delivered homology directed repair (HDR) donor templates represents a powerful approach. However, the challenge of effectively suppressing leaky transcription from the rAAV vector, a phenomenon associated to cytotoxicity, persists. In this study, we demonstrated substantial promoter activities of various homology arms and inverted terminal repeats (ITR).
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- Melittin and its derivatives are being explored to enhance gene delivery systems, particularly in improving the efficiency of recombinant adeno-associated virus (rAAV) vectors for liver cancer treatment.
- Various melittin-derived peptides were tested for their effects on rAAV vector performance, revealing that the p5RHH-rAAV2 vector was notably effective in transducing resistant cell lines and showed promise in both in vitro and in vivo settings.
- The study identified several mechanisms through which melittin analogs enhance gene delivery, particularly emphasizing the role of endosome acidification in facilitating transgene expression.
Glycogen synthase kinase 3 beta (GSK3β) has emerged as a therapeutic target for breast cancer. As inhibitors of GSK-3β, 1,2,4-thiadiazole-3,5-dione (TDZD) family members have been reported as potential candidates for cancer treatment. In this study, the anticancer effects of ethiadin (ETD-174), one of the chemical synthesis compounds of TDZD, were investigated in MCF-7 human breast cancer cells.
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