Iran J Basic Med Sci
September 2021
Objectives: Outer inflammatory protein A (OipA) is an essential adhesin of . We aimed to evaluate the effects of a recombinant OipA in the induction of crucial cytokines as a vaccine candidate and propolis as an adjuvant in C57BL/6 mice.
Materials And Methods: C57BL/6 mice were divided into nine groups according to the disposition of antigen and adjuvant and route of administration: subcutaneous (sc) or gavage.
Background: Regarding the important role of proinflammatory outer membrane protein (OipA) in the pathogenesis of infection and immunomodulatory activity of propolis, we aimed to evaluate the immunogenicity effect of a purified recombinant OipA protein and propolis in the induction of two cytokines, interferon-gamma (IFN-γ) and interleukin-4 (IL-4), in a macrophage cell model.
Materials And Methods: The recombinant protein used in the present study corresponding to the expressing a 34-35 kDa protein. OipA protein was purified by Ni-NTA affinity chromatography.
Background: Bacterial pericarditis is an important cause of post-surgery mortality and morbidity. This can be a preventable complication and the involved pathogens vary according to the time and location.
Objectives: The aim of this study was to investigate the bacteriologic profile in patients with pericardial infections after cardiac surgery in the largest tertiary care center for cardiovascular diseases in Iran.
Background: Catheter Related Blood stream Infections (CRBSI) are prevalent and a potentially fatal complication pertaining to cardiovascular implant devices. There have been no major studies on bacterial colonization of catheters in cardiovascular patients in Iran.
Objectives: To evaluate the incidence of catheter colonization of bacteria in the largest Iranian cardiovascular center.