The antipsychotic-like effects of clozapine in C57BL/6 mice exposed to cuprizone: Decreased glial activation.

Cuprizone (CPZ), a copper chelator that has been shown to selectively damage white matter, can induce a novel animal model to mimic some symptoms of schizophrenia. This study aimed to examine the effect of clozapine (CLZ) on behavioural changes induced by CPZ exposure and try to explore the underlying mechanisms. Behavioural abnormalities associated with feeding mice a 0.

Neurological outcome and predictive factors of idiopathic optic neuritis in China.

Background: The neurological outcome and predictive factors of idiopathic optic neuritis (ION) in China are largely unknown.

Objective: The aim of this paper is to study the neurological outcome of Chinese ION and to investigate the early predictors for multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD).

Method: Retrospective medical record review and supplementary follow-up of 107 ION patients was performed.