Publications by authors named "Heng-Xian He"
Article Synopsis
- Bicyclic scaffolds are important in drug discovery due to their ability to resemble benzene structures.
- This study presents a novel method using a Lewis acid catalyst to facilitate a reaction between bicyclobutanes and diaziridines, yielding valuable azabicyclo[3.1.1]heptane compounds with high efficiency.
- The research also successfully scaled up the process and introduced a chiral zinc-based catalyst to promote enantioselective synthesis, achieving significant optical purity.
The absence of catalytic asymmetric methods for synthesizing chiral (hetero)bicyclo[n.1.1]alkanes has hindered their application in new drug discovery.
View Article and Find Full Text PDFThe cycloaddition reaction involving bicyclo[1.1.0]butanes (BCBs) offers a versatile and efficient synthetic platform for producing C(sp)-rich rigid bridged ring scaffolds, which act as phenyl bioisosteres.
View Article and Find Full Text PDF