Publications by authors named "Heng-Min Xu"
Gastric cancer is a leading cause of cancer-related deaths in China. Affecting more than 40% of the world's population, Helicobacter pylori is a major risk factor for gastric cancer. While previous clinical trials indicated that eradication of H.
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- The study explores how Helicobacter pylori treatment and nutritional supplementation might help prevent gastric cancer (GC) and investigates whether these benefits apply differently to individuals based on their genetic risks.
- It utilizes data from two major cohort studies in China, examining genetic variants linked to the progression of gastric lesions and overall GC risk, with a focus on polygenic risk scores to classify participants.
- Results indicate significant associations between genetic variants and GC risk, revealing that those with higher polygenic risk scores (PRS) are more susceptible to GC, highlighting the potential impact of targeted treatment and nutritional strategies in high-risk groups.