The ethanolic extract of Artemisia anomala exerts anti-inflammatory effects via inhibition of NLRP3 inflammasome.

Background: Artemisia anomala S. Moore (Compositae), known as "Nan-Liu-Ji-Nu" in traditional Chinese medicine (TCM), has been used to treat many inflammatory diseases, including enteritis, acute icteric hepatitis, rheumatism, toothache, tonsillitis, and chronic bronchitis, for centuries. Our preliminary studies have demonstrated that the ethanolic extract of A.

Biphenyl-type neolignans from stem bark of Magnolia officinalis with potential anti-tumor activity.

Six new biphenyl-type neolignans (1-6), and eighteen known compounds (7-24) were isolated from the EtOH extract of Magnolia officinalis. Their structures were determined by 1D and 2D NMR, and by HRMS. The anti-tumor activities of the isolated compounds were evaluated on HepG2, HCT-116, H1975 and HUVEC cell lines.

Flavonoids with Inhibitory Effects on NLRP3 Inflammasome Activation from .

Eight new flavonoids, including two β-hydroxy/methoxychalcones, velutones A and B ( and ), two 1,3-diarylpropan-1-ols, velutols C and D ( and ), a dihydroxychalcone, velutone E (), a chalcone, velutone F (), a furanoflavanone, velutone G (), and a furanoflavonol, velutone H (), and 14 known compounds were isolated from . Their structures were determined by high-resolution electrospray ionisation mass spectrometry (HR-ESIMS) and spectroscopic data analyses and time-dependent density functional theory electronic circular dichroism (TD-DFT-ECD) calculations. Among the isolated constituents, compound exhibited the most potent inhibitory effect (IC: 1.