Publications by authors named "Heng-Chuan Xue"
Article Synopsis
- The study evaluates the outcomes of esophagectomy combined with extended 2-field lymph node dissection in 1,690 patients with esophageal cancer from 1987 to 2008.
- Lymph node metastasis was observed in 42.2% of patients, with significant rates in both thoracic and abdominal areas, while postoperative complications occurred in 16.4% of cases, primarily pulmonary issues.
- Survival rates were reported at 88.2% for one year, decreasing to 30.8% by ten years, with a notable disparity between patients with and without lymph node metastasis in terms of survival.
Background & Objective: As one of the principal causes of gene inactivation, aberrant hypermethylation in the promoter of cancer-related genes has attracted more and more attention. However, such studies on esophageal cancer are still limited. This study was to investigate the association between aberrant hypermethylation of MGMT gene and clinical characteristics as well as MTHFR C677T genetic polymorphisms in esophageal squamous cell carcinoma in a Chinese population.
View Article and Find Full Text PDFTo explore the role of aberrant hypermethylation of cancer-related genes, such as P16, MGMT, and hMLH1, in the esophageal squamous cell carcinoma (ESCC) as well as its relation to dietary folate intake and MTHFR C677T polymorphism, we conducted a molecular epidemiologic study in China. One hundred and twenty-five histologically confirmed ESCC patients having undergone surgery in the Yangzhong People's Hospital between January 2005 and March 2006 were recruited. The aberrant CpG island hypermethylation of P16, MGMT, and hMLH1 genes could be found in cancer tissues with frequency of about 88.
View Article and Find Full Text PDFObjective: This study aims to investigate the risk of esophageal squamous cell carcinoma in relation to exogenous factors in a rural area of China with a high incidence of esophageal squamous cell carcinoma.
Methods: A population-based case-control study was conducted in Yangzhong County, Jiangsu Province, China, with 355 histologically confirmed esophageal squamous cell carcinoma cases recruited between 1 January 2004 and 28 February 2006 and 408 controls matched by sex and age, randomly selected from the local population.
Results: Stratified logistic regression analysis by sex revealed that hot-temperature food items, pork braised in brown sauce and old stocked rice intake could increase the risk of esophageal squamous cell carcinoma with odds ratio of 2.
[Right para-tracheal triangle lymphadenectomy for esophageal carcinoma].
Zhonghua Zhong Liu Za Zhi
July 2003
Objective: To investigate the incidence of lymph node metastasis (LNM) in the right para-tracheal triangle (RPT) of esophageal carcinoma patients and the technique of dissection.
Methods: On the top of double mediastinal and abdominal lymphadenectomy, 333 esophageal carcinoma patients received RPT lymphadenectomy through the right pleural apical approach from 1990 to 2001.
Results: In these 333 patients, the lymph node metastasis (LNM) rate in the RPT was 36.