Publications by authors named "Heng Wen"
Article Synopsis
- - Cobalt-free, nickel-rich layered oxides are promising for high-energy lithium-ion batteries but struggle with structural instability and poor reaction kinetics.
- - A new doping method using higher oxidation state elements like Zr and Mo, along with magnesium, can enhance these materials' electrochemical properties and stability.
- - The co-doping strategy improves capacity retention significantly (87.5% after 210 cycles), showcasing its importance for advancing sustainable and effective lithium-ion battery technology.
Background: Influenza is a highly contagious respiratory disease which poses a serious threat to public health globally, causing severe diseases in 3-5 million humans and resulting in 650,000 deaths annually. The current licensed seasonal influenza vaccines lacked cross-reactivity against novel emerging influenza strains as they conferred limited neutralising capabilities. To address the issue, we designed a multi-epitope peptide-based vaccine delivered by the self-adjuvanting PLGA nanoparticles against influenza infections.
View Article and Find Full Text PDFInfectious diseases have always been regarded as one of the greatest global threats for the last century. The current ongoing COVID-19 pandemic caused by SARS-CoV-2 is living proof that the world is still threatened by emerging infectious diseases. Morbidity and mortality rates of diseases caused by Coronavirus have inflicted devastating social and economic outcomes.
View Article and Find Full Text PDFLung adenocarcinoma (LUAD) is a life-threatening malignant tumor, contributing for the largest cancer burden worldwide. Tumor microenvironment (TME) is composed of various immune cells, stromal cells and tumor cells, which is highly associated with the cancer prognosis and the response to immunotherapy, in which macrophages in TME have been revealing a potential target for cancer treatment. In this study, we sought to further explore the role of macrophages in LUAD progression and establish a risk model related to macrophages for LUAD.
View Article and Find Full Text PDFArticle Synopsis
- Tetrahydropalmatine (THP), derived from the Chinese medicine Corydalis yanhusuo, has been shown to alleviate acute lung injury caused by limb ischemia-reperfusion in rats.
- The study involved pretreating rats with THP and observing its effects on lung weight, inflammatory markers, and macrophage polarization in response to serum from both healthy and injured conditions.
- Findings indicated that THP not only reduced inflammation and improved lung conditions but also shifted macrophage behavior from an inflammatory state (M1) to a healing state (M2) by inhibiting the TLR4/NF-κB/NLRP3 signaling pathway.
In Asian societies, the responsibility of caring for persons with dementia often falls upon an immediate family member. However, little attention has been paid to the early stages of caregiving, as well as their transition into a more experienced caregiver. Thus, a qualitative descriptive study involving a purposive sample of 11 main family caregivers of a person with newly diagnosed dementia was recruited from a tertiary hospital in Singapore.
View Article and Find Full Text PDFBackground: This prospective research aimed to determine the incidence of and risk factors for localized pain at the epidural insertion site following nonobstetric surgery performed with epidural anesthesia.
Methods: A total of 5083 surgical inpatients at the teaching hospital undergoing epidural anesthesia were included in the study. The characteristics of the patients, preoperative basic diseases, details of the epidural techniques, surgical procedures and complications were recorded pre-anesthesia until the complications resolved.
Background: Limb ischemia/reperfusion (I/R) is a common clinical process that frequently induces acute lung injury (ALI). Tetrahydropalmatine (THP) is a major bioactive constituent of various traditional Chinese medicine with protective effects on inflammation and oxidation. In this study, we aimed to investigate the possible protective effect of THP on ALI induced by limb I/R.
View Article and Find Full Text PDFPenehyclidine hydrochloride (PHC) suppresses renal ischemia and reperfusion (I/R) injury (IRI); however, the underlying mechanism of action that achieves this function remains largely unknown. The present study aimed to investigate the potential role of autophagy in PHC‑induced suppression of renal IRI, as well as the involvement of cell proliferation and apoptosis. A rat IRI model and a cellular hypoxia/oxygenation (H/R) model were established; PHC, 3‑methyladenine (3‑MA) and rapamycin (Rapa) were administered to the IRI model rats prior to I/R induction and to H/R cells following reperfusion.
View Article and Find Full Text PDFBackground: Although peritoneal lavage with povidone-iodine (PVPI) is frequently performed after surgery on the gastrointestinal tract, the effects of PVPI on the intestinal epithelial barrier are unknown. The purpose of this study was to investigate the effects of abdominal irrigation with PVPI on the intestinal epithelial barrier in a colorectal cancer (CRC)-induced rat model.
Materials And Methods: The CRC model was induced in rats with azoxymethane and dextran sodium sulfate.