The quasi-1D antimony selenosulfide (Sb(S,Se)) light-harvesting material has attracted tremendous attention for photovoltaic applications because of its superior materials and optoelectronic properties. However, one of the critical obstacles faced by Sb(S,Se) solar cells is the presence of many defects in absorbers, especially those deep-level anion-vacancy defects which are prone to serving as recombination centers. In this work, an effective defect engineering strategy via magnesium chloride (MgCl) postgrowth activation is explored for high performance antimony selenosulfide solar cells.
View Article and Find Full Text PDFEnzymatic nucleic acid reaction is a fundamental tool in molecular biology. However, high-complexity enzymatic DNA reactions and assays are still challenging due to the difficulties in integrating and scaling up microscale reaction units and mixing tools. Here, we present scalable acoustofluidic platform featuring acoustic virtual stirrer (AVS) arrays, serving as stirrers to increase the efficiency of interfacial enzymatic nucleic acid reactions.
View Article and Find Full Text PDFAutism spectrum disorder (ASD) is a type of neurodevelopmental disorder characterized by atypical brain development. Previous whole-brain BrainAGE studies have unveiled the presence of accelerated or delayed brain function developmental patterns in individuals with ASD. However, it remains unclear whether these patterns manifest at a global level throughout the entire brain or are specific to certain functional sub-networks.
View Article and Find Full Text PDFJ Infect Dev Ctries
January 2025
Introduction: Coronavirus disease 2019 (COVID-19) continues to pose a significant public health threat, requiring epidemiological and genomic surveillance. Next generation sequencing (NGS) is commonly utilized for monitoring viral evolution at a high cost. This study evaluated pooled sequencing as a cost-effective tool for monitoring virus variants.
View Article and Find Full Text PDFThis article compares the population agglomeration characteristics of the Xi'an metropolitan area in western China with those of metropolitan areas in other regions officially approved by the Chinese government. The kernel density estimation method and Markov chain model were used to conduct the study. The results revealed that from 2010 to 2020, the population agglomeration level of the Xi'an metropolitan area showed a trend of first increasing and then decreasing.
View Article and Find Full Text PDFThe application of chitosan in packaging has always been limited due to its brittle and hygroscopic nature. In this study, hydrophobic short-chain fatty acids (SCFAs) were utilized to modify chitosan to overcome this issue. For the first time, hydrophobic SCFAs, typically hexanoic acid and its homologs, were found to be able to dissolve chitosan in water as well as its hydrophilic analog.
View Article and Find Full Text PDFTrends Pharmacol Sci
February 2025
The process by which cells translate external mechanical cues into intracellular biochemical signals involves intricate mechanisms that remain unclear. In recent years, research into post-translational modifications (PTMs) has offered valuable insights into this field, spotlighting protein prenylation as a crucial mechanism in cellular mechanotransduction and various human diseases. Protein prenylation, which involves the covalent attachment of isoprenoid groups to specific substrate proteins, profoundly affects the functions of key mechanotransduction proteins such as Rho, Ras, and lamins.
View Article and Find Full Text PDFBioorg Med Chem Lett
April 2025
Harmaline as a natural compound possessed a wide range of pharmacological activities. In this study, 22 novel harmaline-based derivatives were synthesized and screened for in vitro anti-proliferation activity against three cancer cell lines, HCT116, MCF7, and MGC803. The modification site was at the position N-9 of harmaline.
View Article and Find Full Text PDFIntroduction: Antibody-drug conjugates (ADCs) are increasingly utilized in patients with solid tumors and hematologic malignancies. However, the adverse ocular toxicity induced by ADCs has not been comprehensively evaluated in real-world clinical settings.
Methods: Data from April 2019 to March 2024 based on the FDA Adverse Event Reporting System (FAERS) were extracted and analyzed.
Introduction: In recent years, the frequency and intensity of natural disasters and public emergencies around the world have been steadily increasing. Emergency logistics plays an irreplaceable role in providing rapid material and service support in the aftermath of disasters. Therefore, systematically analyzing the differences in emergency logistics responsiveness across various regions of China and understanding their underlying causes are of great significance for optimizing emergency logistics systems and improving disaster responsiveness.
View Article and Find Full Text PDFThe treatment of bone defects remains a great clinical challenge. With the development of science and technology, bone tissue engineering technology has emerged, which can mimic the structure and function of natural bone tissues and create solutions for repairing or replacing human bone tissues based on biocompatible materials, cells and bioactive factors. Hydrogels are favoured by researchers due to their high water content, degradability and good biocompatibility.
View Article and Find Full Text PDFChin J Traumatol
December 2024
Purpose: To investigate the protective effect of sub-hypothermic mechanical perfusion combined with membrane lung oxygenation on ischemic hypoxic injury of yorkshire brain tissue caused by traumatic blood loss.
Methods: This article performed a random controlled trial. Brain tissue of 7 yorkshire was selected and divided into the sub-low temperature anterograde machine perfusion group (n = 4) and the blank control group (n = 3) using the random number table method.
Acute myeloid leukemia (AML), which is most common in adults, is a challenging hematological malignancy. The occurrence and the progression of AML are often accompanied by various gene fusions and/or mutations. Herein, we report the first case of a fusion transcript with a translocation of (1;12)(q25;p13) in AML progressed from myelodysplastic syndrome (MDS) combined with an -ITD (internal tandem duplication) mutation.
View Article and Find Full Text PDFCompared to quantitative real-time PCR (q-PCR), CRISPR-Cas-mediated technology is more suitable for point-of-care testing (POCT) and has potential for wider application in the future. Generally, the operational procedure of CRISPR-Cas-mediated diagnostic method consists of two independent steps, the reaction of signal amplification and the CRISPR-Cas-mediated signal detection. Complex multi-step procedures can easily lead to cross-contamination.
View Article and Find Full Text PDFBackground: Liver injury from drug-drug interactions (DDIs), notably with anti-tuberculosis drugs such as isoniazid, poses a significant safety concern. Electronic medical records contain comprehensive clinical information and have gained increasing attention as a potential resource for DDI detection. However, a substantial portion of adverse drug reaction (ADR) information is hidden in unstructured narrative text, which has yet to be efficiently harnessed, thereby introducing bias into the research.
View Article and Find Full Text PDFWith the development of the social economy, research on stock market prediction is in full swing. However, the fluctuations in stock price and returns are influenced by many factors, including political policies, market environment, investor psychology, and so on. The traditional analysis method, based on subjective experience, requires significant time and effort, and its prediction accuracy is often poor.
View Article and Find Full Text PDFACS Appl Mater Interfaces
December 2024
Information processing is a critical topic in the digital age, as silicon-based circuits face unprecedented challenges such as data explosion, immense energy consumption, and approaching physical limits. Deoxyribonucleic acid (DNA), naturally selected as a carrier for storing and using genetic information, possesses unique advantages for information processing, which has given rise to the emerging fields of DNA computing and DNA data storage. To meet the growing practical demands, a wide variety of materials and interfaces have been introduced into DNA information processing technologies, leading to significant advancements.
View Article and Find Full Text PDFLow back pain caused by intervertebral disc degeneration (IDD) has emerged as a significant global public health concern, with far-reaching consequences for patients' quality of life and healthcare systems. Although previous research have revealed that the mechanisms of intervertebral disc cell apoptosis, pyroptosis and necroptosis can aggravate IDD damage by mediating inflammation and promoting extracellular matrix degradation, but they cannot explain the connection between different cell death mechanisms and ion metabolism disorders. The latest study shows that cell death mechanisms such as cellular senescence, ferroptosis, and cuproptosis, and PANopotosis have similar roles in the progression of intervertebral disc degeneration, but not exactly the same damage mechanism.
View Article and Find Full Text PDFInt J Mol Sci
November 2024
Amino acids are the main form of nitrogen in plants, and their transport across cell membranes relies on amino acid transporters (AATs). Among the plant AATs, the TaATLa subfamily comprises 18 members, yet the bioinformatics characteristics and functions of genes in common wheat remain poorly understood due to their complex genomes. This study performed genomic analyses of .
View Article and Find Full Text PDFWith the continuous spread of the SARS-CoV-2 globally, viral mutations have accumulated. As a result, SARS-CoV-2 became more contagious, and has a higher risk of immune escape and reinfection. To identify variants and have an awareness of the prevalence of these variants, this study selected four segments containing mutations on the S gene of the SARS-CoV-2.
View Article and Find Full Text PDFA critical step in the development of a convergent synthesis of an MRGPRX2 antagonist () was the S2 reaction with a highly functionalized lactamide electrophile and a unique difluoropiperidine nucleophile containing a pyridine -oxide moiety. Initial reactions with sulfonate leaving groups exhibited superb stereoselectivity, but yields were very low due to side reactions originated from competitive Kornblum reactions of the pyridine -oxide and the sulfonates. Markedly improved reaction profiles were achieved by including stoichiometric lithium triflate.
View Article and Find Full Text PDFTo assess the impact of China's regional emergency logistics response capabilities on economic growth sustainability, this study develops a set of comprehensive indicators. It applies the entropy weight method combined with the TOPSIS method to evaluate these capabilities across regions. Based on panel data from 30 provinces in China from 2012 to 2021, this study employs panel models, panel quantile regression, and panel threshold models to analyze the impact of emergency logistics response capability on sustainable economic growth.
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