Publications by authors named "Hendrika T Wessels"
Article Synopsis
- Leptin plays a key role in the onset of puberty and its levels rise prior to pubertal development, but the mechanism behind this increase is unclear.
- A study with 19 children experiencing delayed puberty investigated the impact of pulsatile GnRH administration on leptin levels.
- Results showed that after 36 hours of pulsatile GnRH treatment, leptin levels significantly increased, suggesting that pulsatile GnRH release activates the mechanism that raises leptin concentrations at puberty onset.
Unlabelled: It has been recently shown that male LH-independent sexual precocity is caused by a somatic activating mutation in the luteinising hormone receptor (LHR) of Leydig cell tumours. In each of the patients described to date, the tumour was a well-defined, single encapsulated nodule. We present a 5.
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