CD33+ CD14- phenotype is characteristic of multinuclear osteoclast-like cells in giant cell tumor of bone.

Giant cell tumor of bone (GCTB) is a benign bone tumor with a shown clinical behavior of local recurrences and rare distant metastases. GCTB is composed of uniformly distributed osteoclastic giant cells, thought to originate from the fusion of monocyte-macrophage lineage cells, in a background consisting of mononuclear rounded cells and spindle-shaped cells. Several reports showed the specific expression of markers, such as CD14 on the mononuclear rounded cell population, however, lacking osteoclastic giant cells.

Norbert Goormaghtigh and his contribution to the histophysiology of the kidney.

Norbert Goormaghtigh was born in Ostend on February 14, 1890 and died in Sint-Martens-Latem (Belgium) on January 2, 1960. He was chief of pathology in Ghent from 1923 and became well known for his studies on the structure of the adrenal gland. He started his studies on the kidney and its juxtaglomerular apparatus at the beginning of the thirties carrying on from previous observations made by Ruiter, Borst and Zimmerman, and in 1932 he provided evidence of its endocrine function.

Dedifferentiated adamantinoma with revertant mesenchymal phenotype.

In adamantinoma of long bones, an osteofibrous dysplasia-like form with scattered epithelial elements and a classic form with abundant epithelium are distinguished. Osteofibrous dysplasia-like adamantinomas occur in children and adolescents and behave relatively benign, whereas classic adamantinomas predominate in adults and have a more aggressive clinical course. Because some osteofibrous dysplasia-like tumors have progressed to classic adamantinomas, it is hypothesized that the former is a potential precursor of the latter, showing mesenchymal-to-epithelial transformation.