Publications by authors named "Hend Hassan Abdel-Sattar"
Article Synopsis
- The study investigates Losartan potassium-laden pegylated nanocubic vesicles (LP-NCVs-PEG) as a targeted treatment for acute renal injury, focusing on blocking cell death and activating protective pathways in the kidneys.
- Researchers optimized a formulation process to enhance drug delivery efficiency, resulting in LP-NCVs-PEG that protect against stomach conditions and specifically target kidney tissue with reduced side effects.
- Findings show that LP-NCVs-PEG significantly improve the drug’s bioavailability and reduce renal damage by altering expression of several key proteins, indicating potential as a protective therapy for kidney injuries.
More than 1 billion people worldwide suffer from hypertension; therefore, hypertension management has been categorized as a global health priority. Losartan potassium (LP) is an antihypertensive drug with a limited oral bioavailability of about 33% since it undergoes the initial metabolic cycle. Thus, nasal administration is a unique route to overcome first-pass metabolism.
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