Publications by authors named "Hend E El-Gahel"
Purpose: To test the involvement between IL-18 and IL-6 genetic polymorphisms and susceptibility to Type 1 diabetes (T1D).
Methods: Single nucleotide polymorphisms (SNPs) at positions -607A/C and - 137G/C in IL-18 promoter region were examined by sequence specific primers-polymerase chain reaction (SSP-PCR) and position -174G/C in promoter region of IL-6 gene which analyzed by Mutagenically Separated PCR (MS-PCR) in 104 T1D participants and 114 controls.
Results: IL-18 -137GC and -137CC genotypes and -137C allele were significantly decreased in T1D subjects ( < 005), while -137GG genotype was insignificantly increased as compared to controls.