HLA-A*31:01 and carbamazepine-induced DRESS syndrom in a sample of North African population.

Purpose: Drug rash with eosinophilia and systemic symptoms (DRESS) is a serious adverse drug reaction. Carbamazepine is the most common causes of this syndrome. The HLA-A*31:01 allele has been shown to be strongly correlated with carbamazepine-induced DRESS syndrome in European, Japanese, Han Chinese and other asian population but not in African populations.

Paucisymptomatic Dermoid Cyst with Fatal Outcome.

Dermoid cysts of the central nervous system can cause devastating complications because of the mass effect of meningitis due to sinus tract. We report the case of a 5-month-old girl who presented with a crusted lesion of the occipital region of the scalp. Clinical examination noted skin abnormalities suggestive of occult dysraphism.

[Cutaneous adverse drug reaction: prospective study of 118 cases].

Background: Few prospective studies are available on the incidence and analysis of the characteristics of adverse cutaneous drug reactions.

Aim: To describe the adverse cutaneous reactions, their epidemiologic characteristics as well as the different causative drugs through a prospective hospital study.

Methods: A 12-month prospective study was managed in our department of dermatology of the teaching hospital Hedi Chaker of Sfax.